2-花生酰基甘油

2-花生酰基甘油用途

2-Arachidonoylglycerol 是中枢神经系统中的一种内源性大麻素配体。

2-花生酰基甘油名称

[ CAS 号 ]:
53847-30-6

[ 中文名 ]:
2-花生酰基甘油

[ 英文名 ]:
2-arachidonoylglycerol

[英文别名 ]:

MFCD01862600
2-arachidonoylglycerol
2-Arachidonyl Glycerol
EINECS 200-835-2
2-arachidonoyl glycerol

2-花生酰基甘油生物活性

[ 描述 ]:

2-Arachidonoylglycerol 是中枢神经系统中的一种内源性大麻素配体。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体

研究领域 >> 神经疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

2-花生四烯酰甘油(2-AG)是从肠组织分离的大麻素配体。 2-花生四烯酰甘油激活神经元大麻素受体作为完全激动剂,并阻止在CA3-CA1突触中诱导长时程增强。 2-花生四烯酰甘油与大麻素受体结合,并发挥大麻素药物的典型效应[1]。

[参考文献]

[1]. Stella N, et al. A second endogenous cannabinoid that modulates long-term potentiation. Nature. 1997 Aug 21;388(6644):773-8.

[相关活性小分子]

2-花生酰基甘油物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
508.6±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₃H₃₈O₄

[ 分子量 ]:
378.545

[ 闪点 ]:
163.0±23.6 °C

[ 精确质量 ]:
378.277008

[ PSA ]:
66.76000

[ LogP ]:
6.24

[ 外观性状 ]:
液体

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.508

[ 储存条件 ]:
−20°C

2-花生酰基甘油MSDS

详细MSDS(安全技术说明书)

2-花生酰基甘油安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H319

[ 警示性声明 ]:
P210-P261-P280-P305 + P351 + P338-P370 + P378-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;F: Flammable;

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
S26-S36/37

[ 危险品运输编码 ]:
UN 1648 3/PG 2

[ WGK德国 ]:
2

[ 海关编码 ]:
2916190090

2-花生酰基甘油上下游产品

2-花生酰基甘油上游产品

2-花生酰基甘油下游产品

2-花生酰基甘油海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

2-花生酰基甘油文献

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme.

Biochemistry 52(43) , 7559-74, (2013)

The profiles of serine hydrolases in human and mouse macrophages are similar yet different. For instance, human macrophages express high levels of carboxylesterase 1 (CES1), whereas mouse macrophages ...

Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus.

Psychopharmacol. Ser. 232(3) , 583-93, (2015)

To determine the role of the endocannabinoid, 2-arachodonyl glycerol (2-AG), in the regulation of nausea and vomiting.We evaluated the effectiveness of the potent selective monoacylglycerol lipase (MA...

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