7-羟基-4'-甲氧基黄酮

7-羟基-4'-甲氧基黄酮用途

Pratol 是有效的 NF-κB 抑制剂。Pratol 显著降低了 LPS 刺激的 RAW 264.7 细胞中 NO 和前列腺素 PGE2 的产生,且无细胞毒性。Pratol 能减少促炎细胞因子。Pratol 可用于炎性疾病和癌症的研究。

7-羟基-4'-甲氧基黄酮名称

[ CAS 号 ]:
487-24-1

[ 中文名 ]:
车轴草醇

[ 英文名 ]:
7-Hydroxy-4'-methoxyflavone

[英文别名 ]:

Flavone,7-hydroxy-4'-methoxy
7-Hydroxy-4'-methoxyflavone
EINECS 207-653-2
4'-Methoxy-7-hydroxyflavone

7-羟基-4'-甲氧基黄酮生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[参考文献]

[1]. Chung, Y. C. , et al. Anti-inflammatory Effect of Pratol in LPS-stimulated RAW 264.7 Cells via NF-κB Signaling Pathways. Natural Product Communications, 13(5), 1934578X1801300.

7-羟基-4'-甲氧基黄酮物理化学性质

[ 密度 ]:
1.329g/cm3

[ 沸点 ]:
479.4ºC at 760mmHg

[ 熔点 ]:
263-264ºC

[ 分子式 ]:
C₁₆H₁₂O₄

[ 分子量 ]:
268.26

[ 闪点 ]:
183.4ºC

[ 精确质量 ]:
266.09400

[ PSA ]:
39.44000

[ LogP ]:
3.77700

[ 蒸汽压 ]:
8.17E-10mmHg at 25°C

[ 折射率 ]:
1.641

[ 储存条件 ]:
2-8°C，干燥，密封

7-羟基-4'-甲氧基黄酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100110

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-methoxyphenyl)-

CAS REGISTRY NUMBER :: 487-24-1

BEILSTEIN REFERENCE NO. :: 0237239

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-O4

MOLECULAR WEIGHT :: 268.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 38,67,1983

7-羟基-4'-甲氧基黄酮安全信息

[ 危害码 (欧洲) ]:
Xi