波尔定碱

波尔定碱用途

Boldine 是一种从山苍子 (Litsea cubeba) 根中提取的阿扑吗啡异喹啉生物碱,具有抗氧化,抗炎和细胞保护作用。Boldine 抑制破骨细胞生成,通过下调 OPG/RANKL/RANK 信号途径来改善骨破坏,并且可能是类风湿性关节炎的潜在治疗剂。

波尔定碱名称

[ CAS 号 ]:
476-70-0

[ 中文名 ]:
波尔定碱

[ 英文名 ]:
Boldine

[中文别名 ]:

[英文别名 ]:

Boldine chloroform
Boldin
2,6-dihydroxy-3,5-dimethoxyaporphine
EINECS 207-509-9
1,10-dimethoxy-2,9-dihydroxyaporphine
Uniboldina
MFCD00135040
2,9-Dihydroxy-1,10-dimethoxyaporphine
1,10-Dimethoxy-6aa-aporphine-2,9-diol
dl-Boldine

波尔定碱生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[ 靶点 ]

OPG/RANKL/RANK[1]

[参考文献]

[1]. Zhao H , et al. Boldine isolated from Litsea cubeba inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis. Int Immunopharmacol. 2017 Oct;51:114-123.

波尔定碱物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
529.3±50.0 °C at 760 mmHg

[ 熔点 ]:
162-164ºC

[ 分子式 ]:
C₁₉H₂₁NO₄

[ 分子量 ]:
327.374

[ 闪点 ]:
273.9±30.1 °C

[ 精确质量 ]:
327.147064

[ PSA ]:
62.16000

[ LogP ]:
2.32

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.639

波尔定碱MSDS

波尔定碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CE0750000

CHEMICAL NAME :: 6a-alpha-Aporphine-2,9-diol, 1,10-dimethoxy-

CAS REGISTRY NUMBER :: 476-70-0

BEILSTEIN REFERENCE NO. :: 0094036

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C19-H21-N-O4

MOLECULAR WEIGHT :: 327.41

WISWESSER LINE NOTATION :: T C6666 1A Q KN&TT&J EO1 FQ K1 PQ QO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: Gene conversion and mitotic recombination

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 100 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,145,1991

波尔定碱安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
1-20-24/25-45-36-26

[ 危险品运输编码 ]:
UN 1544

[ WGK德国 ]:
3

[ RTECS号 ]:
CE0750000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

波尔定碱合成路线

波尔定碱上下游产品

波尔定碱上游产品

波尔定碱下游产品

波尔定碱文献

Applied biological and physicochemical activity of isoquinoline alkaloids: oxoisoaporphine and boldine.

Molecules 17(9) , 10958-70, (2012)

The aim of this study was to determine the electronic influence of substituent groups and annelated rings such as oxazole-oxazinone on the physicochemical and photoprotection, antioxidant capacity, to...

Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.

Planta Med. 72(12) , 1157-62, (2006)

The extraction methods in selected monographs of the European and the Swiss Pharmacopoeia were compared to pressurized liquid extraction (PLE) with respect to the yield of constituents to be dosed in ...

8-NH2-boldine, an antagonist of alpha1A and alpha1B adrenoceptors without affinity for the alpha1D subtype: structural requirements for aporphines at alpha1-adrenoceptor subtypes.

Planta Med. 71(10) , 897-903, (2005)

Structure-activity analysis of 21 aporphine derivatives was performed by examining their affinities for cloned human alpha (1A), alpha (1B) and alpha (1D) adrenoceptors (AR) using membranes prepared f...

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