(1,1'-联萘)-2,2'-二胺

(1,1'-联萘)-2,2'-二胺用途

1,1'-Binaphthyl-2,2'-diamine 是 (S)-[1,1'-Binaphthalene]-2,2'-diamine (HY-W007978A) 的非活性异构体,可作为实验中的对照化合物。(S)-[1,1'-Binaphthalene]-2,2'-diamine 是一种生化试剂,可作为生物材料或有机化合物,用于生命科学相关研究。

(1,1'-联萘)-2,2'-二胺名称

[ CAS 号 ]:
4488-22-6

[ 中文名 ]:
[1,1’-联萘]-2,2’-二胺

[ 英文名 ]:
UNII:TL35μ1249

[中文别名 ]:

[英文别名 ]:

2,2'-diamino-1,1'-binaphthalene
UNII:TL35μ1249
1,1'-Binaphthalene-2,2'-diamine
1,1-BINAPHY1-2,2'-DIAMINE
(S)-1,1'-binaphthyl-2,2'-diamine
binaphthyldiamine
rac-1,1'-binaphthyl-2,2'-diamine
MFCD00145204
S(-)-DABN
2,2-DIAMINO-1,1'-BINAPHTHALENE

(1,1'-联萘)-2,2'-二胺生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Kettle JG, et al. Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C. J Med Chem. 2022 May 12;65(9):6940-6952.

(1,1'-联萘)-2,2'-二胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
480.8±30.0 °C at 760 mmHg

[ 熔点 ]:
242-244ºC(lit.)

[ 分子式 ]:
C₂₀H₁₆N₂

[ 分子量 ]:
284.35

[ 闪点 ]:
293.9±24.0 °C

[ 精确质量 ]:
284.131348

[ PSA ]:
52.04000

[ LogP ]:
3.85

[ 外观性状 ]:
slightly beige

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.775

[ 储存条件 ]:
室温

[ 水溶解性 ]:
Insoluble in water

(1,1'-联萘)-2,2'-二胺MSDS

详细MSDS(安全技术说明书)

(1,1'-联萘)-2,2'-二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU3090000

CHEMICAL NAME :: (1,1'-Binaphthalene)-2,2'-diamine

CAS REGISTRY NUMBER :: 4488-22-6

BEILSTEIN REFERENCE NO. :: 2138401

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H16-N2

MOLECULAR WEIGHT :: 284.38

WISWESSER LINE NOTATION :: L66J CZ B- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 590 mg/kg/25W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

REFERENCE :: AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40. For publisher information, see CNREA8. Volume(issue)/page/year: 40,62,1940

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 mg/kg/27W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

REFERENCE :: AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40. For publisher information, see CNREA8. Volume(issue)/page/year: 40,62,1940

(1,1'-联萘)-2,2'-二胺安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
36/37/38-41-22

[ 安全声明 (欧洲) ]:
S26;S39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DU3090000

(1,1'-联萘)-2,2'-二胺

(1,1'-联萘)-2,2'-二胺用途

(1,1'-联萘)-2,2'-二胺名称

(1,1'-联萘)-2,2'-二胺生物活性

(1,1'-联萘)-2,2'-二胺物理化学性质

(1,1'-联萘)-2,2'-二胺MSDS

详细MSDS(安全技术说明书)

(1,1'-联萘)-2,2'-二胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

(1,1'-联萘)-2,2'-二胺安全信息

(1,1'-联萘)-2,2'-二胺合成路线

详细合成路线

(1,1'-联萘)-2,2'-二胺上下游产品

(1,1'-联萘)-2,2'-二胺上游产品

(1,1'-联萘)-2,2'-二胺下游产品

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