3,4-二羟基苯甲酸乙酯

3,4-二羟基苯甲酸乙酯用途

Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate) 是一种抗氧化剂,是一种在花生种子的种皮中发现的脯氨酰羟化酶 (prolyl-hydroxylase) 抑制剂。Ethyl 3,4-dihydroxybenzoate 通过激活 NO 合酶 (NO synthase) 并产生线粒体 ROS 来保护心肌。Ethyl 3,4-dihydroxybenzoate 可诱导 ESCC 细胞自噬 (autophagy) 和凋亡 (apoptosis)。Ethyl 3,4-dihydroxybenzoate 是胶原蛋白合成抑制剂,具有骨骼保护作用。

3,4-二羟基苯甲酸乙酯名称

[ CAS 号 ]:
3943-89-3

[ 中文名 ]:
3,4-二羟基苯甲酸乙酯

[ 英文名 ]:
Ethyl 3,4-dihydroxybenzoate

[中文别名 ]:

[英文别名 ]:

3,4-dihydroxybenzoic acid ethyl ether
Ethyl-3,4-dihydroxybenzoate
Benzoic acid, 3,4-dihydroxy-, ethyl ester
Ethyl protocatechuate
EDHB
3,4-Dihydroxybenzoic acid ethyl ester
EINECS 223-529-0
Benzoic acid, 3,4-dihydroxy-, ethyl ester (9CI)
Protocatechuic acid ethyl ester
MFCD00002199

3,4-二羟基苯甲酸乙酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

信号通路 >> 自噬 >> 自噬

信号通路 >> 代谢酶/蛋白酶 >> HIF/HIF脯氨酰-羟化酶

研究领域 >> 代谢疾病

[参考文献]

[1]. Bo Han, et al. A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1. PLoS One. 2014 Sep 18;9(9):e107204.

[2]. Sebastian Philipp, et al. Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H450-7.

[3]. Byeong-Ju Kwon, et al. Ethyl-3,4-dihydroxybenzoate with a dual function of induction of osteogenic differentiation and inhibition of osteoclast differentiation for bone tissue engineering. Tissue Eng Part A. 2014 Nov;20(21-22):2975-84.

[4]. D Nandan, et al. Ethyl-3,4-dihydroxybenzoate inhibits myoblast differentiation: evidence for an essential role of collagen. J Cell Biol. 1990 May;110(5):1673-9.

3,4-二羟基苯甲酸乙酯物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
358.1±22.0 °C at 760 mmHg

[ 熔点 ]:
132-134 °C(lit.)

[ 分子式 ]:
C₉H₁₀O₄

[ 分子量 ]:
182.173

[ 闪点 ]:
147.0±15.8 °C

[ 精确质量 ]:
182.057907

[ PSA ]:
66.76000

[ LogP ]:
2.22

[ 外观性状 ]:
白色晶体或粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.574

[ 储存条件 ]:
室温

[ 水溶解性 ]:
可溶于：甲醇

3,4-二羟基苯甲酸乙酯MSDS

详细MSDS(安全技术说明书)

3,4-二羟基苯甲酸乙酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918290000

3,4-二羟基苯甲酸乙酯合成路线

详细合成路线

3,4-二羟基苯甲酸乙酯上下游产品

3,4-二羟基苯甲酸乙酯上游产品

3,4-二羟基苯甲酸乙酯下游产品

3,4-二羟基苯甲酸乙酯制备

由3，4一二羟基苯甲酸与乙醇酯化而得。

3,4-二羟基苯甲酸乙酯海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

3,4-二羟基苯甲酸乙酯文献

Antioxidant activity of protocatechuates evaluated by DPPH, ORAC, and CAT methods.

Food Chem. 194 , 749-57, (2015)

Hibiscus sabdariffa L. is a worldwide consumed plant, principally after infusion of its dried sepals and calyces, which are usually discarded. Nevertheless, they represent a potential source of natura...

Inhibitory Effect of Dried Pomegranate Concentration Powder on Melanogenesis in B16F10 Melanoma Cells; Involvement of p38 and PKA Signaling Pathways.

Int. J. Mol. Sci. 16 , 24219-42, (2015)

Plants rich in antioxidant substances may be useful for preventing skin aging. Pomegranates, containing flavonoids and other polyphenolic compounds, are widely consumed due to their beneficial propert...

Evidence for a role of collagen synthesis in arterial smooth muscle cell migration.

J. Clin. Invest. 101(9) , 1889-98, (1998)

Migration of smooth muscle cells (SMCs) and collagen synthesis by SMCs are central to the pathophysiology of vascular disease. Both processes can be induced shortly after vascular injury; however, a f...

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