加奈索酮

加奈索酮用途

Ganaxolone, also known as CCD 1042 and C1042, is a CNS-selective GABAA modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects. Ganaxolone protects against seizures in diverse animal models, including the pentylenetetrazol, 6 Hz and amygdala kindling models. Ganaxolone is a positive allosteric modulator of the action of the GABAA receptor and, unlike benzodiazepines, there does not appear to be tolerance to the anticonvulsant effects of ganaxolone.

加奈索酮名称

[ CAS 号 ]:
38398-32-2

[ 中文名 ]:
加奈索酮

[ 英文名 ]:
Ganaxolone

[英文别名 ]:

ccd-1042
Ganaxolone

加奈索酮物理化学性质

[ 密度 ]:
1.036g/cm3

[ 沸点 ]:
434.8ºC at 760mmHg

[ 分子式 ]:
C₂₂H₃₆O₂

[ 分子量 ]:
332.52000

[ 闪点 ]:
185.4ºC

[ 精确质量 ]:
332.27200

[ PSA ]:
37.30000

[ LogP ]:
4.98530

[ 折射率 ]:
1.517

[ 储存条件 ]:
2-8°C，干燥密封

加奈索酮MSDS

详细MSDS(安全技术说明书)

加奈索酮安全信息

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
TU4384700

加奈索酮上下游产品

加奈索酮上游产品

加奈索酮下游产品

加奈索酮文献

A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 976-977 , 6-18, (2015)

Free arachidonic acid is functionally interlinked with different lipid signaling networks including those involving prostanoid pathways, the endocannabinoid system, N-acylethanolamines, as well as ste...

Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human.

Xenobiotica 35 , 191-210, (2005)

The prediction of human pharmacokinetics is often based on in vivo preclinical pharmacokinetic data. However, to date, no clear guidance has been available about the relative ability of the major prec...

Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome.

Behav. Brain Res. 291 , 164-71, (2015)

Silencing the gene FMR1 in fragile X syndrome (FXS) with consequent loss of its protein product, FMRP, results in intellectual disability, hyperactivity, anxiety, seizure disorders, and autism-like be...

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