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异硫氰酸荧光素酯

异硫氰酸荧光素酯用途

FITC是荧光素的衍生物,用于标记胺。

异硫氰酸荧光素酯名称

[ CAS 号 ]:
3326-32-7

[ 中文名 ]:
异硫氰酸荧光素酯

[ 英文名 ]:
Fluorescein isothiocyanate

[中文别名 ]:

[英文别名 ]:

5-FITC
Isothiocyanatofluorescein
5-Isothionatofluorescein
FITC Fluorescein 5-isothiocyanate
EINECS 248-207-7
Fluorescein Isothiosyanate
fluorescein isothiocyanate isomer 1
fluorescein 6-isothiocyanate
FITC ISOMER
Fluorescein 5-Isothiocyanate (isomer I)

异硫氰酸荧光素酯生物活性

[ 描述 ]:

FITC是荧光素的衍生物,用于标记胺。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

染料试剂

研究领域 >> 其他

[体外研究]

Annexin V-FITC/PI用于检测软骨细胞凋亡[1]。 PEI修饰的CD与异硫氰酸荧光素(FITC)缀合以制备CDs-FITC复合物[2]。

[细胞实验]

用膜联蛋白V-荧光素异硫氰酸酯（FITC）和碘化丙啶通过流式细胞术测量软骨细胞凋亡的频率。从每组中收集总共1×104个处理的软骨细胞，在冷PBS中洗涤并在室温下与膜联蛋白V-FITC和PI在黑暗中在冰上孵育15分钟。然后使用荧光激活细胞分选仪分析这些样品。 Cell Quest软件用于分析细胞凋亡的百分比。所有测试重复三次。

[参考文献]

[1]. Gao SG, et al. Phosphorylation of osteopontin has proapoptotic and proinflammatory effects on human knee osteoarthritis chondrocytes. Exp Ther Med. 2016 Nov;12(5):3488-3494. Epub 2016 Oct 5.

[2]. Zhu X, et al. Ratiometric, visual, dual-signal fluorescent sensing and imaging of pH/copper ions in real samples based on carbon dots-fluorescein isothiocyanate composites. Talanta. 2017 Jan 1;162:65-71

[相关活性小分子]

异硫氰酸荧光素酯物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
708.6±60.0 °C at 760 mmHg

[ 熔点 ]:
>360 °C(lit.)

[ 分子式 ]:
C₂₁H₁₁NO₅S

[ 分子量 ]:
389.381

[ 闪点 ]:
382.4±32.9 °C

[ 精确质量 ]:
389.035797

[ PSA ]:
120.44000

[ LogP ]:
4.00

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.754

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stability Stable, but moisture-sensitive. Incompatible with strong oxidizing agents, strong bases, amines, acids.

[ 水溶解性 ]:
practically insoluble

异硫氰酸荧光素酯MSDS

异硫氰酸荧光素酯安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38;R42/43

[ 安全声明 (欧洲) ]:
S22-S45-S36/37/39-S26-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

异硫氰酸荧光素酯合成路线

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异硫氰酸荧光素酯文献

Imaging of a clinically relevant stroke model: glucose hypermetabolism revisited.

Stroke 46(3) , 835-42, (2015)

Ischemic stroke has been shown to cause hypermetabolism of glucose in the ischemic penumbra. Experimental and clinical data indicate that infarct-related systemic hyperglycemia is a potential therapeu...

Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties.

Int. J. Nanomedicine 9 , 2815-32, (2014)

Silica (SiO₂) nanoparticles (NPs) are widely used in diverse industrial and biomedical applications. Their applicability depends on surface modifications, which can limit potential health problems.To ...

Uptake of neutrophil-derived Ym1 protein distinguishes wound macrophages in the absence of interleukin-4 signaling in murine wound healing.

Am. J. Pathol. 184(12) , 3249-61, (2014)

The determination of regenerative wound-healing macrophages as alternatively activated macrophages is currently questioned by the absence of IL-4 in wound tissue. Yet, murine wound tissue expressed hi...

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