<生产厂家价格>

舒布硫胺

舒布硫胺用途

Sulbutiamine 是一种高脂溶性的合成的维生素 B1 类似物,可用于无力症的研究。

舒布硫胺名称

[ CAS 号 ]:
3286-46-2

[ 中文名 ]:
硫锌酸硫胺

[ 英文名 ]:
Sulbutiamine

[中文别名 ]:

舒布硫胺

[英文别名 ]:

MFCD01726427
Arcalion
Vitaverin
bisibutiamine
Fat Black HB
O-Isobutyroylthiamine disulfide
SOLVENT BLACK 3
Vitaberin
O,O'-Diisobutyrylthiamine disulfide
EINECS 221-937-3

舒布硫胺生物活性

[ 描述 ]:

Sulbutiamine 是一种高脂溶性的合成的维生素 B1 类似物,可用于无力症的研究。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

Sulbutiamine对经受氧-葡萄糖剥夺的海马CA1锥体神经元显示出神经保护作用。 Sulbutiamine以浓度依赖性方式增强电生理特性,如兴奋性突触传递和内在神经元膜输入阻力[1]。 Sulbutiamine减弱由血清剥夺诱导的凋亡细胞死亡,并以剂量依赖性方式刺激GSH和GST活性。此外,sulbutiamine可降低切割的caspase-3和AIF的表达[2]。

[参考文献]

[1]. Kwag J, et al. Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons. Biol Pharm Bull. 2011;34(11):1759-64.

[2]. Kang KD, et al. Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells. Neurochem Res. 2010 Nov;35(11):1828-39.

[相关活性小分子]

舒布硫胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
726.0±60.0 °C at 760 mmHg

[ 熔点 ]:
140.5-141.5 °C

[ 分子式 ]:
C₃₂H₄₆N₈O₆S₂

[ 分子量 ]:
702.89

[ 闪点 ]:
392.9±32.9 °C

[ PSA ]:
247.42000

[ LogP ]:
7.51

[ 外观性状 ]:
白色至类白色粉末

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.702

[ 储存条件 ]:
库房通风低温干燥

舒布硫胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ2721000

CHEMICAL NAME :: Formamide, N,N'-(dithiobis(2-(2-hydroxyethyl)-1-methylvinylene)) bis(N-((4-amino-2-met hyl-5- pyrimidinyl)methyl)-, diisobutyrate (ester)

CAS REGISTRY NUMBER :: 3286-46-2

BEILSTEIN REFERENCE NO. :: 0741531

LAST UPDATED :: 199712

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C32-H46-N8-O6-S2

MOLECULAR WEIGHT :: 702.98

WISWESSER LINE NOTATION :: T6N CNJ B1 DZ E1NVHY1&UY2OVY1&1&SSY2OVY1&1&UY1&NVH1- ET6N CNJ B1 DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,606,1982

舒布硫胺安全信息

[ 危害码 (欧洲) ]:
Xi