乙酰辅酶A三锂盐

乙酰辅酶A三锂盐用途

乙酰辅酶A(Acetyl-CoA)锂是一种膜无氧中心代谢中间体,参与TCA循环和氧化磷酸化代谢。乙酰辅酶A锂通过提供(唯一供体)乙酰基来靶向氨基酸残基,以实现蛋白质翻译后乙酰化反应,从而调节各种细胞机制。乙酰辅酶A锂也是脂质合成的关键前体[1][2][3][4]。

乙酰辅酶A三锂盐名称

[ CAS 号 ]:
32140-51-5

[ 中文名 ]:
乙酰辅酶A,锂盐

[ 英文名 ]:
Acetyl coenzyme A lithium

[中文别名 ]:

乙酰辅酶A三锂盐

[英文别名 ]:

Acetyl-S-CoA Li3
acetyl-CoA
Acetyl coenzyme A lithium salt
Lithiumacetyl-CoA

乙酰辅酶A三锂盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 自噬 >> 自噬

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

乙酰辅酶A锂增加饥饿U2OS细胞的细胞质蛋白乙酰化,同时减少饥饿诱导的自噬通量。(U2OS细胞稳定表达GFP-LC3,并微量注射乙酰辅酶A锂；在100 nM BafA1存在的无营养条件下培养,3小时后固定)[2]。

[体内研究]

乙酰辅酶A锂通过抑制适应不良的自噬作用减弱小鼠心脏压力过载模型中压力过载引起的心肌病[2][3]。剥夺食物(但可以自由饮水)24小时的小鼠,在包括心脏和肌肉在内的几个器官中,乙酰辅酶a锂的总含量显著降低,相应的蛋白质乙酰化水平降低。然而,相同的实验条件对脑内乙酰辅酶A锂浓度没有重大影响,实际上会增加肝脏乙酰辅酶A-锂和蛋白质乙酰化水平[4]。

[参考文献]

[1]. Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50.

[2]. Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25.

[3]. Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93.

[4]. Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21.

乙酰辅酶A三锂盐物理化学性质

[ 分子式 ]:
C₂₃H₃₅Li₃N₇O₁₇P₃S

[ 分子量 ]:
827.37000

[ 精确质量 ]:
827.15000

[ PSA ]:
426.85000

[ LogP ]:
1.36220

[ 储存条件 ]:
2-8°C

乙酰辅酶A三锂盐MSDS

详细MSDS(安全技术说明书)

乙酰辅酶A三锂盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危险品运输编码 ]:
NONH for all modes of transport

乙酰辅酶A三锂盐文献

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Proc. Natl. Acad. Sci. U. S. A. 98(4) , 2017-22, (2001)

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Arch. Neurol. 60(5) , 761-3, (2003)

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Productive infection and bICP0 early promoter activity of bovine herpesvirus 1 are stimulated by E2F1.

J. Virol. 84(13) , 6308-17, (2010)

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