5-溴-5-硝基-1,3-二噁烷

5-溴-5-硝基-1,3-二噁烷用途

5-Bromo-5-nitro-1,3-dioxane 是一种抗菌化合物,可有效对抗革兰氏阳性和革兰氏阴性细菌和真菌,包括酵母。5-Bromo-5-nitro-1,3-dioxane 通过必需蛋白硫醇的氧化抑制酶活性并随后抑制微生物的生长。

5-溴-5-硝基-1,3-二噁烷名称

[ CAS 号 ]:
30007-47-7

[ 中文名 ]:
5-溴-5-硝基-1,3-二恶烷

[ 英文名 ]:
Bronidox

[中文别名 ]:

[英文别名 ]:

EINECS 250-001-7
5-bromo-5-nitro-1,3-dioxolane
5-Bromo-5-nitro-m-dioxane
5-bromo-5-nitro-1,3-dioxan
5-Bromo-5-nitro-1,3-dioxane
1,3-Dioxane, 5-bromo-5-nitro-
m-Dioxane, 5-bromo-5-nitro-
MFCD00101855
m-DIOXANE,5-BROMO-5-NITRO
1,3-Dioxane,5-bromo-5-nitro

5-溴-5-硝基-1,3-二噁烷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. M Ghannoum, et al. Mode of Action of the Antimicrobial Compound 5-bromo-5-nitro-1,3-dioxane (Bronidox). Folia Microbiol (Praha). 1986;31(1):19-31.

5-溴-5-硝基-1,3-二噁烷物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
280.8±40.0 °C at 760 mmHg

[ 熔点 ]:
60°C

[ 分子式 ]:
C₄H₆BrNO₄

[ 分子量 ]:
211.999

[ 闪点 ]:
123.6±27.3 °C

[ 精确质量 ]:
210.948013

[ PSA ]:
64.28000

[ LogP ]:
0.95

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
库房通风低温干燥,与食品原料类分开存放

[ 水溶解性 ]:
可溶于：甲醇

5-溴-5-硝基-1,3-二噁烷MSDS

5-溴-5-硝基-1,3-二噁烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JG9650000

CHEMICAL NAME :: m-Dioxane, 5-bromo-5-nitro-

CAS REGISTRY NUMBER :: 30007-47-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H6-Br-N-O4

MOLECULAR WEIGHT :: 212.02

WISWESSER LINE NOTATION :: T6O COTJ EE ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 455 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

5-溴-5-硝基-1,3-二噁烷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R38

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
1759

[ WGK德国 ]:
3

[ RTECS号 ]:
JG9650000

[ 海关编码 ]:
2934999090

5-溴-5-硝基-1,3-二噁烷合成路线

5-溴-5-硝基-1,3-二噁烷上下游产品

5-溴-5-硝基-1,3-二噁烷上游产品

5-溴-5-硝基-1,3-二噁烷下游产品

5-溴-5-硝基-1,3-二噁烷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-溴-5-硝基-1,3-二噁烷文献

Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox).

Folia Microbiol. (Praha) 31 , 19-31, (1986)

The mode of action of the antimicrobial agent, 5-bromo-5-nitro-1,3-dioxane (bronidox), was studied in detail for gram-positive and gram-negative bacteria, yeast and fungi. The studies included MIC tes...

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