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三乙烯二胺

三乙烯二胺用途

1,4-二氮杂双环[2.2.2]辛烷是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

三乙烯二胺名称

[ CAS 号 ]:
280-57-9

[ 中文名 ]:
三乙烯二胺

[ 英文名 ]:
DABCO

[中文别名 ]:

[英文别名 ]:

T66 A B CN FNTJ
UNII-X8M57R0JS5
1,4-diazabicyclo-[2.2.2]octane
dabco33lv
1,4-Diazabicyclo[2.2.2]octane
1,4-diazabicyclo-[2.2.2]-octane
DABCO
TEDA-L33
diazabicyclooctane
1,4-diazabicyclo(2.2.2) octane

三乙烯二胺生物活性

[ 描述 ]:

1,4-二氮杂双环[2.2.2]辛烷是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

1,4个-二氮杂双环[2.2.2]辛烷用作聚氨酯催化剂,巴里斯·希尔曼反应催化剂络合配体和路易斯碱。它可用于染料激光器和荧光显微镜的样品镶嵌,以及作为抗褪色剂显示可清除由于荧光染料激发荧光染料而产生的复仇女神自由基。此外,它还是一种氧化和聚合催化剂。

三乙烯二胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
174.0±0.0 °C at 760 mmHg

[ 熔点 ]:
156-159 °C(lit.)

[ 分子式 ]:
C₆H₁₂N₂

[ 分子量 ]:
112.17

[ 闪点 ]:
62.2±0.0 °C

[ 精确质量 ]:
112.100044

[ PSA ]:
6.48000

[ LogP ]:
-0.85

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
1.2±0.3 mmHg at 25°C

[ 折射率 ]:
1.561

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable, but very hygroscopic. Incompatible with strong oxidizing agents, strong acids. Highly flammable.

[ 水溶解性 ]:
46 g/100 mL (26 ºC)

三乙烯二胺MSDS

三乙烯二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HM0354200

CHEMICAL NAME :: 1,4-Diazabicyclo(2,2,2)octane

CAS REGISTRY NUMBER :: 280-57-9

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C6-H12-N2

MOLECULAR WEIGHT :: 112.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,522,1962

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,522,1962 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4680 mg/kg/26W-I

TOXIC EFFECTS :: Behavioral - alteration of classical conditioning Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0905 No. of Facilities: 334 (estimated) No. of Industries: 9 No. of Occupations: 15 No. of Employees: 1710 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0905 No. of Facilities: 1104 (estimated) No. of Industries: 23 No. of Occupations: 30 No. of Employees: 33913 (estimated) No. of Female Employees: 5787 (estimated)

三乙烯二胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335-H412

[ 警示性声明 ]:
P261-P273-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R22;R36/38;R41;R52/53

[ 安全声明 (欧洲) ]:
S26-S60-S37/39-S3-S16-S36/37

[ 危险品运输编码 ]:
UN 1325 4.1/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
HM0354200

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29335920

三乙烯二胺合成路线

三乙烯二胺上下游产品

三乙烯二胺上游产品

三乙烯二胺下游产品

三乙烯二胺制备

1、将1,2-二氯乙烷和氨水送入管式反应器中，于150-250℃、392kPa压力下进和热压氨化反应。反应液以碱中和得到混合游离胺，经浓缩除去氯化钠，然后将粗吕减压蒸馏，收集不同馏分进行分离。在获得该品同时，并联产乙二胺、二亚乙基三胺、三亚乙基四胺、四亚乙基五胺和多亚乙基多胺。从生产六水哌嗪的母液中经分馏可得该品，第生产100t六水哌嗪可得六水三亚乙基二胺约3-4t。

2、由N-羟乙基哌嗪合成TEDA在内径为24cm的固定床反应器中添入40-60ml的BaSr2型催化剂（钡锶质量比为3.6：1），升温至设定温度，用计量泵输入40%-60%的原料水溶液，原料气空速为615-219h，粗羟乙基哌嗪进入反应器经预热汽化后与催化剂床层接触反应。合成三乙烯二胺的工艺条件为：反应温度为355-370℃，N-羟乙基哌嗪水溶液的含量为60%（质量分数），原料气空速为20000h，催化剂颗粒直径为2mm。在此条件下，粗羟乙基哌嗪的转化率为100%，三乙烯二胺的选择为90%，纯度达99%以上。

从生产六水哌嗪的母液中经分馏也可得到本品。

3、以羟乙基哌嗪或双羟乙基哌嗪为原料，在催化剂作用下，高温进行环化反应，制取三亚乙基二胺。

4、二氯乙烷和氨水进行热压氨解反应，反应液用碱中和，得混合游离胺，再经浓缩，同时除去副产物氯化钠，然后将粗品进行减压精馏，即可得成品。或者在生产六水哌嗪时经分馏可得三乙烯二胺。

5、以乙二胺或乙醇胺、二乙醇胺或二乙烯三胺为原料制取时，只能达到中等程度的产率。例如，二乙烯三胺在常压和360℃的温度下，以86%二氧化硅和12%氧化铝组成的催化剂进行反应，可以制得同等产量的哌嗪、烷基哌嗪、吡嗪以及乙二胺和除了双环化合物之外的同系物。再经蒸馏，以丙酮再结晶和石
油醚洗涤，即可得到纯度为95%的三乙烯二胺，再经升华处理后纯度可以达到98%。

6、以羟乙基哌嗪或双羟乙基哌嗪为原料，在高温下进行环化反应，制取三乙烯二胺。所用催化剂有氧化铝、活性白土、磷酸锆等。例如，将羟乙基哌嗪通过内装煅烧过APO-9（由磷酸与勃姆石反应的产物）催化剂的反应管，控制管内反应温度在400℃，可制得三乙烯二胺，产率在81.4%。

三乙烯二胺海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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