1-甲基-色氨酸

1-甲基-色氨酸用途

(Rac)-Indoximod (1-Methyl-DL-tryptophan) 是吲哚胺-2,3-双加氧酶 (IDO) 抑制剂。(Rac)-Indoximod 和 IFN-γ 联用显著降低了表达 α-SMA 的人心肌成纤维细胞活性,并通过上调 IRF-1,Fas 和 FasL 基因诱导凋亡(apoptosis)。

1-甲基-色氨酸名称

[ CAS 号 ]:
26988-72-7

[ 中文名 ]:
1-甲基-DL-色氨酸

[ 英文名 ]:
(Rac)-Indoximod

[中文别名 ]:

1-甲基-色氨酸

[英文别名 ]:

racemic N-methyl tryptophan
methyl tryptophan
1-methyl-D,L-tryptophan
DL-1-Methyltryptophan
1-MT
EINECS 248-157-6
racemic-1-methyl-D-tryptophan
MFCD00005803
2-amino-3-(1-methylindol-3-yl)propanoic acid
L-Tryptophan,1-methyl

1-甲基-色氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 吲哚胺2,3-二氧化酶(IDO)

研究领域 >> 炎症/免疫

[ 靶点 ]

IDO

[体外研究]

(Rac)-吲哚肟(1-甲基-DL-色氨酸；0.5 mM；3天)抑制色氨酸耗竭,从而部分逆转IFN-γ的生长抑制活性,但不管色氨酸耗竭,最终都会诱导细胞死亡[1]。细胞活力测定[1]细胞系：人心脏肌成纤维细胞(hCMs)浓度：0.5mm孵育时间：3d结果：IFN-γ对生长的阻滞作用在第2天部分逆转,但第3天细胞活力进一步降低。

[参考文献]

[1]. Jun-Won Lee,et al. Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosis. Mol Cell Biochem. 2019 Aug;458(1-2):197-205.

1-甲基-色氨酸物理化学性质

[ 密度 ]:
1.28g/cm3

[ 沸点 ]:
429.3ºC at 760mmHg

[ 熔点 ]:
250ºC (dec.)(lit.)

[ 分子式 ]:
C₁₂H₁₄N₂O₂

[ 分子量 ]:
218.25200

[ 闪点 ]:
213.4ºC

[ 精确质量 ]:
218.10600

[ PSA ]:
68.25000

[ LogP ]:
1.83300

[ 储存条件 ]:
室温，密闭，干燥

1-甲基-色氨酸MSDS

详细MSDS(安全技术说明书)

1-甲基-色氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

1-甲基-色氨酸上下游产品

1-甲基-色氨酸上游产品

1-甲基-色氨酸下游产品

1-甲基-色氨酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-甲基-色氨酸文献

Substrate promiscuity of the cyclic dipeptide prenyltransferases from Aspergillus fumigatus ( section sign).

J. Nat. Prod. 72 , 44-52, (2009)

This study reports that a series of tryptophan derivatives with modifications on the side chain or at the indole ring were accepted by two cyclic dipeptide prenyltransferases, CdpNPT and FtmPT1, and c...

Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice.

Cardiovasc. Res. 106 , 295-302, (2015)

Atherosclerosis is a chronic inflammatory disease that is initiated by the retention and accumulation of low-density lipoprotein in the artery, leading to maladaptive response of cells from the immune...

Immunosuppressive properties of Wharton's jelly-derived mesenchymal stromal cells in vitro.

Int. J. Hematol. 102 , 368-78, (2015)

Recent studies have reported that mesenchymal stromal cells (MSCs) migrate to areas of inflammation and suppress adverse immune reactions. Bone marrow (BM)-derived MSCs have been successfully used in ...

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