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4-乙烯基苯酚,min10%丙二醇溶液

4-乙烯基苯酚,min10%丙二醇溶液用途

4-Vinylphenol 存在于药用草白花蛇舌草,野生稻中,也是葡萄酒中乳酸菌对对香豆酸和阿魏酸的代谢产物。4-Vinylphenol 诱导凋亡 (apoptosis),在体内抑制血管形成并抑制浸润性乳腺肿瘤生长。

4-乙烯基苯酚,min10%丙二醇溶液名称

[ CAS 号 ]:
2628-17-3

[ 中文名 ]:
4-羟基苯乙烯

[ 英文名 ]:
4-Vinylphenol

[中文别名 ]:

4-乙烯基苯酚

[英文别名 ]:

EINECS 220-103-6
4-ethenylphenol
MFCD00017593
p-Hydroxystyrene
4-vinyl phenol
para-hydroxystyrene
Phenol, 4-ethenyl-
4-Vinylphenol
p-vinylphenol
1-hydroxy-4-vinylbenzene

4-乙烯基苯酚,min10%丙二醇溶液生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[体外研究]

4-乙烯基苯酚(12.5-200微克/毫升)显著降低了亲本MDA-MB-231细胞的活力,IC50值为109微克/毫升[1]。4-乙烯基苯酚(0.15或0.3微克/毫升；3天)可减少乳腺癌细胞的球形形成和波形蛋白表达[1]。4-乙烯基苯酚(50,100微克/毫升；72小时)显著抑制富含CSC的MDA-MB-231细胞的增殖。4-乙烯基苯酚显著降低富含CSC的MDA-MB-231细胞中ALDH1A1表达50%[1]。4-乙烯基苯酚(100微克/毫升)显著增加caspase 3的表达,可能使富含CSC的MDAMB-231细胞对凋亡敏感[1]。

[参考文献]

[1]. Leung HW, et al. The natural agent 4-vinylphenol targets metastasis and stemness features in breast cancer stem-like cells. Cancer Chemother Pharmacol. 2018 Aug;82(2):185-197.

4-乙烯基苯酚,min10%丙二醇溶液物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
206.2±9.0 °C at 760 mmHg

[ 熔点 ]:
73 °C

[ 分子式 ]:
C₈H₈O

[ 分子量 ]:
120.148

[ 闪点 ]:
92.3±8.4 °C

[ 精确质量 ]:
120.057518

[ PSA ]:
20.23000

[ LogP ]:
2.16

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.602

[ 储存条件 ]:
-20°C，惰性气体环境

4-乙烯基苯酚,min10%丙二醇溶液毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN3800000

CHEMICAL NAME :: Phenol, p-vinyl-

CAS REGISTRY NUMBER :: 2628-17-3

BEILSTEIN REFERENCE NO. :: 0506844

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H8-O

MOLECULAR WEIGHT :: 120.16

WISWESSER LINE NOTATION :: QR D1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-1285-0579S ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Skin and Appendages - corrosive (after topical exposure)

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-1285-0579S

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Ocular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-1285-0579S ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1400 mg/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 195,575,1977

4-乙烯基苯酚,min10%丙二醇溶液安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26-S39

[ WGK德国 ]:
2

[ RTECS号 ]:
SN3800000

[ 海关编码 ]:
2907199090

4-乙烯基苯酚,min10%丙二醇溶液制备

1. 烟草：BU，56；FC，BU，OR，18。

4-乙烯基苯酚,min10%丙二醇溶液海关

[ 海关编码 ]: 2907199090

[ 中文概述 ]:
2907199090 其他一元酚. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%