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4-氨基-2-氯-6, 7-二氧基喹唑啉

4-氨基-2-氯-6, 7-二氧基喹唑啉用途

【用途一】
用于合成哌唑嗪、多沙唑嗪、特拉唑嗪、阿夫唑嗪等药物
【用途二】
医药中间体，用于合成哌唑嗪、多沙唑嗪、特拉唑嗪等药物。。
【用途三】
医药中间体，用于合成哌唑嗪、多沙唑嗪、特拉唑嗪等药物

4-氨基-2-氯-6, 7-二氧基喹唑啉名称

[ CAS 号 ]:
23680-84-4

[ 中文名 ]:
2-氯-4-氨基-6,7-二甲氧基喹唑啉

[ 英文名 ]:
2-Chloro-6,7-dimethoxyquinazolin-4-amine

[中文别名 ]:

[英文别名 ]:

2-chloro-6,7-dimethoxy-4-aminoquinazoline
2-chloro-6,7-dimethoxyquinazolin-4-amine
EINECS 245-821-7
2-Chloro-4-amino-6,7-dimethoxyquinazoline
2-chlor-6,7-dimethoxychinazolin-4-amin
2-Chloro-4-AMino-6
7-DiMethoxy-Quinazoline
MFCD00051734
QUINAZOLINAMINE
4-Amino-2-Chloro-6,7-Dimethoxyquinoline

4-氨基-2-氯-6, 7-二氧基喹唑啉物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
374.0±42.0 °C at 760 mmHg

[ 熔点 ]:
262-268 °C (dec.)(lit.)

[ 分子式 ]:
C₁₀H₁₀ClN₃O₂

[ 分子量 ]:
239.658

[ 闪点 ]:
180.0±27.9 °C

[ 精确质量 ]:
239.046158

[ PSA ]:
70.26000

[ LogP ]:
1.54

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.649

[ 储存条件 ]:
2-8°C

4-氨基-2-氯-6, 7-二氧基喹唑啉MSDS

4-氨基-2-氯-6, 7-二氧基喹唑啉安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

4-氨基-2-氯-6, 7-二氧基喹唑啉合成路线

4-氨基-2-氯-6, 7-二氧基喹唑啉上下游产品

4-氨基-2-氯-6, 7-二氧基喹唑啉上游产品

4-氨基-2-氯-6, 7-二氧基喹唑啉下游产品

4-氨基-2-氯-6, 7-二氧基喹唑啉海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-氨基-2-氯-6, 7-二氧基喹唑啉文献

Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist.

J. Med. Chem. 39 , 4602, (1996)

The enantiomers of [4-(4-amino-6, 7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-1-yl]-fu ran- 2-ylmethanone (cyclazosin, 1) were synthesized from the chiral furan-2-yl(cis-octahydroquinoxalin-1-...

2,4-Diamino-6,7-dimethoxyquinazolines. 3. 2-(4-Heterocyclylpiperazin-1-yl) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.

J. Med. Chem. 30(10) , 1794-8, (1987)

A series of 4-amino-6,7-dimethoxy-2(4-heterocyclylpiperazin-1-yl)quinazolines (3) was prepared and screened for alpha-adrenoceptor affinity and antihypertensive activity. These quinazoline derivatives...

2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.

J. Med. Chem. 30(6) , 999-1003, (1987)

A series of 4-amino-2-(4-carbamoylpiperidino)-6,7-dimethoxyquinazolines (2) were synthesized and evaluated for alpha-adrenoceptor affinity and antihypertensive activity. These compounds displayed high...

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