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1-甲基-3-苯基丙胺

1-甲基-3-苯基丙胺用途

【用途一】
是制造心血管药物柳胺苄心定的中间体

1-甲基-3-苯基丙胺名称

[ CAS 号 ]:
22374-89-6

[ 中文名 ]:
1-甲基-3-苯基丙胺

[ 英文名 ]:
4-phenylbutan-2-amine

[中文别名 ]:

2-氨基-4-苯基丁烷

[英文别名 ]:

DL-1-methyl-3-phenyl-n-propylamine
α-Methyl phenethylamine
1-Methyl-3-phenylpropylamine
Benzenepropanamine, α-methyl-
1-phenyl-3-aminobutane
4-phenylbutan-2-amine
3-Amino-1-phenylbutane
EINECS 244-942-2
(RS)-1-methyl-3-phenylpropylamine
(+/-)-1-methyl-3-phenylpropylamine

1-甲基-3-苯基丙胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
221.5±0.0 °C at 760 mmHg

[ 熔点 ]:
-50ºC

[ 分子式 ]:
C₁₀H₁₅N

[ 分子量 ]:
149.233

[ 闪点 ]:
97.8±0.0 °C

[ 精确质量 ]:
149.120453

[ PSA ]:
26.02000

[ LogP ]:
2.18

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.522

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
8.5 g/L (20 ºC)

1-甲基-3-苯基丙胺MSDS

1-甲基-3-苯基丙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UI3920000

CHEMICAL NAME :: Propylamine, alpha-methyl-gamma-phenyl-

CAS REGISTRY NUMBER :: 22374-89-6

BEILSTEIN REFERENCE NO. :: 2413110

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H15-N

MOLECULAR WEIGHT :: 149.26

WISWESSER LINE NOTATION :: ZY1&2R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 195,647,1940

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 195,647,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 195,647,1940

1-甲基-3-苯基丙胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C: Corrosive;Xi: Irritant;T: Toxic;F: Flammable;

[ 风险声明 (欧洲) ]:
R22;R34

[ 安全声明 (欧洲) ]:
26-36/37/39-45-28A-36/37

[ 危险品运输编码 ]:
UN 2735 8/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
UI3920000

[ 包装等级 ]:
III

[ 海关编码 ]:
29214980

1-甲基-3-苯基丙胺合成路线

1-甲基-3-苯基丙胺上下游产品

1-甲基-3-苯基丙胺上游产品

1-甲基-3-苯基丙胺下游产品

1-甲基-3-苯基丙胺制备

1-甲基-3-苯基丙胺海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

1-甲基-3-苯基丙胺文献

Quantification of Methylphenidate, Dexamphetamine, and Atomoxetine in Human Serum and Oral Fluid by HPLC With Fluorescence Detection.

Ther. Drug Monit. 38 , 98-107, (2016)

For psychostimulants, a marked individual variability in the dose-response relationship and large differences in plasma concentrations after similar doses are known. Therefore, optimizing the efficacy...

Identification and quantitation of an oxidative metabolite of labetalol in sheep: pharmacokinetic and metabolic implications.

Biol. Mass Spectrom. 21(11) , 534-40, (1992)

A sensitive and selective assay has been developed for the identification and quantitation of 3-amino-1-phenyl butane (3-APB), a metabolite of labetalol, in biological fluids using electron impact gas...

Disposition, metabolism, and pharmacodynamics of labetalol in adult sheep.

Drug Metab. Dispos. 21(2) , 284-92, (1993)

Labetalol causes significant maternal and fetal metabolic effects in pregnant sheep (Yeleswaram et al., J. Pharmacol. Exp. Ther. 262, 683-691 (1992)). This study was undertaken to investigate the cont...

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