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番石榴苷

番石榴苷用途

Guaijaverin 是一种尿素酶抑制剂,IC50 值为 120 μM。Guaijaverin 具有抗氧化和抗变形链球菌活性。

番石榴苷名称

[ CAS 号 ]:
22255-13-6

[ 中文名 ]:
番石榴苷

[ 英文名 ]:
Guaijaverin

[中文别名 ]:

[英文别名 ]:

Quercetin-3-Arabinoside
Quercetin 3-O-α-L-arabinoside
Quercetin 3-O-alpha-L-arabinoside

番石榴苷生物活性

[ 描述 ]:

Guaijaverin 是一种尿素酶抑制剂,IC50 值为 120 μM。Guaijaverin 具有抗氧化和抗变形链球菌活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

IC50: 120 μM (Urease)[1]

[体外研究]

Guaijaverin具有抗Strep.mutans活性,MTCC 1943和CLSM 001菌株的MIC值为4和2mg/ml。突变体,分别[3]。

[参考文献]

[1]. Shabana S, et al. Inhibitory activity against urease of quercetin glycosides isolated from Allium cepa and Psidium guajava. Biosci Biotechnol Biochem. 2010;74(4):878-80.

[2]. Caruso IP, et al. Exploring the binding mechanism of Guaijaverin to human serum albumin: fluorescencespectroscopy and computational approach. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov;97:449-55.

[3]. Prabu GR, et al. Guaijaverin -- a plant flavonoid as potential antiplaque agent against Streptococcus mutans. J Appl Microbiol. 2006 Aug;101(2):487-95.

番石榴苷物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
828.1±65.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₁₈O₁₁

[ 分子量 ]:
434.350

[ 闪点 ]:
296.3±27.8 °C

[ 精确质量 ]:
434.084900

[ PSA ]:
190.28000

[ LogP ]:
1.68

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.802

[ 储存条件 ]:
room temp

番石榴苷MSDS

详细MSDS(安全技术说明书)

番石榴苷安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

番石榴苷文献

Inhibitory activity against urease of quercetin glycosides isolated from Allium cepa and Psidium guajava.

Biosci. Biotechnol. Biochem. 74 , 878-880, (2010)

Methanolic extracts of edible plants and seaweeds were tested for their inhibitory activity against Jack bean urease. Quercetin-4'-O-beta-D-glucopyranoside was isolated from Allium cepa as a urease in...

Guaijaverin -- a plant flavonoid as potential antiplaque agent against Streptococcus mutans.

J. Appl. Microbiol. 101 , 487-495, (2006)

The aim of the present study was to investigate the anti-Streptococcus mutans activity and the in vitro effects of subminimal inhibitory concentrations of guaijaverin isolated from Psidium guajava Lin...

Benzophenones and flavonoids from Hypericum maculatum and their antioxidant activities.

Nat. Prod. Res. 26 , 1576-1583, (2012)

The occurrence of three known benzophenones, namely annulatophenonoside, acetylannulatophenonoside and annulatophenone as well as a flavonol O-glycoside guajaverin in the aerial parts of Hypericum mac...

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