25-羟基胆固醇

25-羟基胆固醇用途

25-Hydroxycholesterol 是胆固醇的代谢产物,由巨噬细胞响应 Toll 样受体 (TLR) 激活而产生和分泌。25-Hydroxycholesterol 有效且选择性抑制 B 细胞产生 IgA,EC50 约为 65 nM。

25-羟基胆固醇名称

[ CAS 号 ]:
2140-46-7

[ 中文名 ]:
25-羟基胆甾醇

[ 英文名 ]:
25-Hydroxycholesterol

[中文别名 ]:

[英文别名 ]:

25-Hydroxy Cholesterol
(3β,9β,14β)-Cholest-5-ene-3,25-diol
Cholest-5-ene-3,25-diol, (3β,9β,14β)-

25-羟基胆固醇生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

天然产物 >> 类固醇

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

25-羟基胆固醇的合成由胆固醇25-羟化酶催化,胆固醇25-羟化酶使用胆固醇和分子氧作为底物,NADPH作为辅助因子。 25-羟基胆固醇是先天性和适应性免疫系统中的一种有效的生物活性脂质[1]。

[参考文献]

[1]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.

[相关活性小分子]

25-羟基胆固醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
513.1±23.0 °C at 760 mmHg

[ 分子式 ]:
C₂₇H₄₆O₂

[ 分子量 ]:
402.653

[ 闪点 ]:
213.5±17.2 °C

[ 精确质量 ]:
402.349792

[ PSA ]:
40.46000

[ LogP ]:
7.66

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.538

[ 储存条件 ]:
2-8℃

25-羟基胆固醇MSDS

25-羟基胆固醇安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H315-H319-H332-H335-H373

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22-36/37/38-48

[ 安全声明 (欧洲) ]:
26-36-45

[ 危险品运输编码 ]:
NONH for all modes of transport

25-羟基胆固醇合成路线

25-羟基胆固醇文献

Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.

Gynecol. Oncol. 135(2) , 333-41, (2014)

Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin-OXysterol).Ovarian cancer cell lines were treated with combinations of statins and oxys...

The effects of Zanthoxylum bungeanum extract on lipid metabolism induced by sterols.

J. Pharmacol. Sci. 127(3) , 251-9, (2015)

Variant pharmacological activities of Zanthoxylum bungeanum were determined before. The aim of this study was to assess whether Z. bungeanum could regulate lipid metabolism. The cholesterol overloadin...

Specific cellular incorporation of a pyrene-labelled cholesterol: lipoprotein-mediated delivery toward ordered intracellular membranes.

PLoS ONE 10(4) , e0121563, (2015)

In the aim of testing tools for tracing cell trafficking of exogenous cholesterol, two fluorescent derivatives of cholesterol, 22-nitrobenzoxadiazole-cholesterol (NBD-Chol) and 21-methylpyrenyl-choles...

更多文献

25-羟基胆固醇

25-羟基胆固醇用途

25-羟基胆固醇名称

25-羟基胆固醇生物活性

25-羟基胆固醇物理化学性质

25-羟基胆固醇MSDS

详细MSDS(安全技术说明书)

25-羟基胆固醇安全信息

25-羟基胆固醇合成路线

详细合成路线

25-羟基胆固醇文献

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