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甲基补骨脂黄酮

甲基补骨脂黄酮用途

Bavachinin(7-O-Methylbavachin)是一天然化合物,具有抗炎症和抗血管生成活性。

甲基补骨脂黄酮名称

[ CAS 号 ]:
19879-30-2

[ 中文名 ]:
甲基补骨脂黄酮A

[ 英文名 ]:
Bavachinin

[中文别名 ]:

[英文别名 ]:

Bavachinin
7-O-Methylbavachin
Bavachinin A

甲基补骨脂黄酮生物活性

[ 描述 ]:

Bavachinin(7-O-Methylbavachin)是一天然化合物,具有抗炎症和抗血管生成活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 黄酮类化合物

研究领域 >> 炎症/免疫

[参考文献]

[1]. Chen X, et al. Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro. FEBS Lett. 2013 Sep 17;587(18):2930-5.

[2]. Nepal M, et al. Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1α. Eur J Pharmacol. 2012 Sep 15;691(1-3):28-37.

[3]. Chen X, et al. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs. Cell Mol Immunol. 2013 Nov;10(6):497-505.

[相关活性小分子]

甲基补骨脂黄酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
537.1±50.0 °C at 760 mmHg

[ 熔点 ]:
139-145ºC

[ 分子式 ]:
C₂₁H₂₂O₄

[ 分子量 ]:
338.397

[ 闪点 ]:
190.3±23.6 °C

[ 精确质量 ]:
338.151794

[ PSA ]:
55.76000

[ LogP ]:
4.93

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.590

[ 储存条件 ]:
?20°C

甲基补骨脂黄酮MSDS

详细MSDS(安全技术说明书)

甲基补骨脂黄酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2981791

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2,3-dihydro-2-(4-hydroxyphenyl)-7-methoxy-6-(3-methyl -2-butenyl)-, (S)-

CAS REGISTRY NUMBER :: 19879-30-2

BEILSTEIN REFERENCE NO. :: 3629340

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H22-O4

MOLECULAR WEIGHT :: 338.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: INDRBA Indian Drugs. (Indian Drugs Manufacturers' Assoc., 102B, Poonam Chambers, Dr. A. B. Rd., Worli, Bombay 400 018, India) V.1- 1963- Volume(issue)/page/year: 29,662,1992

甲基补骨脂黄酮安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 危害码 (欧洲) ]:
N

[ 风险声明 (欧洲) ]:
50

[ 安全声明 (欧洲) ]:
61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

甲基补骨脂黄酮文献

Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation.

Planta Med. 78(9) , 903-6, (2012)

Inhibiting interleukin-6 (IL-6) has been postulated as an effective therapy in the pathogenesis of several inflammatory diseases. In this study, seven flavonoids were isolated from the methanol extrac...

Antioxidative components of Psoralea corylifolia (Leguminosae).

Phytother Res. 16(6) , 539-44, (2002)

A meroterpene and four flavonoids were isolated from the seeds of Psoralea corylifolia as antioxidative components. Their structures were elucidated by spectral data and identified as bakuchiol (1), b...

Development of a fully automated on-line solid phase extraction and high-performance liquid chromatography with diode array detection method for the pharmacokinetic evaluation of bavachinin: a study on absolute bioavailability and dose proportionality.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 893-894 , 21-8, (2012)

A fully automated on-line solid-phase extraction (SPE) and high-performance liquid chromatography (HPLC) with diode array detection (DAD) method was developed for determination of bavachinin in mouse ...

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