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(-)-儿茶素

(-)-儿茶素用途

(-)-Catechin 从绿茶中分离的,是 Catechin 的一种异构体。Catechin 抑制环加氧酶-1 (COX-1) , IC50 为 1.4 μM。

(-)-儿茶素名称

[ CAS 号 ]:
18829-70-4

[ 中文名 ]:
(-)-儿茶素

[ 英文名 ]:
(-)-catechin

[中文别名 ]:

(-)-儿茶酚,儿茶酸,邻苯二酚

[英文别名 ]:

ent-catechin
MFCD00180760
(-)-Catechin
EINECS 242-611-7
(−)-Catechin
Catechin l-form

(-)-儿茶素生物活性

[ 描述 ]:

(-)-Catechin 从绿茶中分离的,是 Catechin 的一种异构体。Catechin 抑制环加氧酶-1 (COX-1) , IC50 为 1.4 μM。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 免疫及炎症 >> COX

[参考文献]

[1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9.

(-)-儿茶素物理化学性质

[ 密度 ]:
1.593 g/cm3

[ 沸点 ]:
630.4ºC at 760 mmHg

[ 熔点 ]:
175-176ºC

[ 分子式 ]:
C₁₅H₁₄O₆

[ 分子量 ]:
290.26800

[ 闪点 ]:
335ºC

[ 精确质量 ]:
290.07900

[ PSA ]:
110.38000

[ LogP ]:
1.54610

[ 外观性状 ]:
固体粉末

[ 蒸汽压 ]:
1.09E-20mmHg at 25°C

[ 储存条件 ]:
2-8°C

(-)-儿茶素MSDS

详细MSDS(安全技术说明书)

(-)-儿茶素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

(-)-儿茶素文献

An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.

J. Nat. Prod. 73 , 1193-5, (2010)

Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple fo...

The blood pressure effect and related plasma levels of flavan-3-ols in spontaneously hypertensive rats.

Food Funct. 6 , 3479-89, (2015)

We studied the short-term antihypertensive effect of flavan-3-ols (-)-epicatechin, (+)-catechin and (-)-catechin, in spontaneously hypertensive rats (SHR). Plasma metabolites and the corresponding pla...

Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi.

Eur. J. Med. Chem. 50 , 230-5, (2012)

Bioassay guided fractionation of ethanolic extract of the leaves of Bauhinia racemosa led to the isolation of galactolipid and catechin class of the compounds (1-7) from the most active n-butanol frac...

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