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3-肟-6,7-二氯-1H-吲哚-2,3-二酮

3-肟-6,7-二氯-1H-吲哚-2,3-二酮用途

NS309是钙离子激活的钾离子通道(KCa2和KCa3.1)的阳性调节剂,能增强钙离子的敏感性,对BK通道无活性。

3-肟-6,7-二氯-1H-吲哚-2,3-二酮名称

[ CAS 号 ]:
18711-16-5

[ 中文名 ]:
3-肟-6,7-二氯-1H-吲哚-2,3-二酮

[ 英文名 ]:
NS309

[中文别名 ]:

6,7-二氯-1H-吲哚-2,3-二酮-3-肟

[英文别名 ]:

1H-Indole-2,3-dione, 6,7-dichloro-, 3-oxime, (3E)-
NS-309
6,7-dichloro-1H-indole-2,3-dione-3-oxime
6,7-dichloroisatin 3-oxime
1H-Indole-2,3-dione, 6,7-dichloro-, 3-oxime
6,7-Dichloro-1H-indole-2,3-dione 3-oxime
3-Oxime-6,7-dichloro-1H-indole-2,3-dione
NS309

3-肟-6,7-二氯-1H-吲哚-2,3-二酮生物活性

[ 描述 ]:

NS309是钙离子激活的钾离子通道(KCa2和KCa3.1)的阳性调节剂,能增强钙离子的敏感性,对BK通道无活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钾通道

研究领域 >> 心血管疾病

[参考文献]

[1]. Stankevicius, Edgaras; Dalsgaard, Thomas; Kroigaard, Christel et al. Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizin

[2]. Seear, Rachel V.; Lew, Virgilio L. IKCa agonist (NS309)-elicited all-or-none dehydration response of human red blood cells is cell-age dependent. Cell Calcium (2011), 50(5), 444-448.

[3]. Dalsgaard, T.; Kroigaard, C.; Misfeldt, M. Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. British Journal of Pharmacology (2010), 160(6), 1496-1508

[4]. Broendum, E.; Kold-Petersen, H.; Simonsen, U.; Aalkjaer, C. NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats. British Journal of Pharmacology (2010), 159(1), 154-165.

[相关活性小分子]

3-肟-6,7-二氯-1H-吲哚-2,3-二酮物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 分子式 ]:
C₈H₄Cl₂N₂O₂

[ 分子量 ]:
231.036

[ 精确质量 ]:
229.964981

[ PSA ]:
61.69000

[ LogP ]:
2.66

[ 折射率 ]:
1.742

[ 储存条件 ]:
2-8℃

3-肟-6,7-二氯-1H-吲哚-2,3-二酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933790090

3-肟-6,7-二氯-1H-吲哚-2,3-二酮海关

[ 海关编码 ]: 2933790090

[ 中文概述 ]:
2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:9.0% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

3-肟-6,7-二氯-1H-吲哚-2,3-二酮文献

Inactivation of Endothelial Small/Intermediate Conductance of Calcium-Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients.

J. Am. Heart Assoc. 4 , e002062, (2015)

Diabetes is associated with coronary arteriolar endothelial dysfunction. We investigated the role of the small/intermediate (SK(Ca)/IK(Ca)) conductance of calcium-activated potassium channels in diabe...

Duration differences of corticostriatal responses in striatal projection neurons depend on calcium activated potassium currents.

Front. Syst. Neurosci. 7 , 63, (2013)

The firing of striatal projection neurons (SPNs) exhibits afterhyperpolarizing potentials (AHPs) that determine discharge frequency. They are in part generated by Ca(2+)-activated K(+)-currents involv...

Stimulation of large-conductance calcium-activated potassium channels inhibits neurogenic contraction of human bladder from patients with urinary symptoms and reverses acetic acid-induced bladder hyperactivity in rats.

Eur. J. Pharmacol. 735 , 68-76, (2014)

We have analysed the effects of large-conductance calcium-activated potassium channel (BK) stimulation on neurogenic and myogenic contraction of human bladder from healthy subjects and patients with u...

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