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L-犬尿氨酸硫酸盐

L-犬尿氨酸硫酸盐用途

L-犬尿氨酸硫酸盐,一种芳香烃受体(AHR)激动剂,可激活AHR导向的原始T细胞极化至抗炎性Treg表型【1】。

L-犬尿氨酸硫酸盐名称

[ CAS 号 ]:
16055-80-4

[ 中文名 ]:
L-犬尿氨酸硫酸盐

[ 英文名 ]:
L -Kynurenine sulfate salt

[英文别名 ]:

L-kynurenin,sulfate
L-KYNURENINESULPHATE
L-Kynurenin,Sulfat
L-Kynurenine sulfate salt crystalline
Kyn sulfate
L-Kynurenine sulfate salt

L-犬尿氨酸硫酸盐生物活性

[ 描述 ]:

L-犬尿氨酸硫酸盐,一种芳香烃受体(AHR)激动剂,可激活AHR导向的原始T细胞极化至抗炎性Treg表型【1】。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 芳基烃受体

研究领域 >> 炎症/免疫

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Benjamin J Moyer, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.

L-犬尿氨酸硫酸盐物理化学性质

[ 沸点 ]:
466.6ºC at 760 mmHg

[ 熔点 ]:
196 °C

[ 分子式 ]:
C₁₀H₁₄N₂O₇S

[ 分子量 ]:
306.29200

[ 闪点 ]:
236ºC

[ 精确质量 ]:
306.05200

[ PSA ]:
189.39000

[ LogP ]:
1.96300

[ 外观性状 ]:
浅黄色固体

[ 蒸汽压 ]:
1.66E-09mmHg at 25°C

[ 储存条件 ]:
-20°C

L-犬尿氨酸硫酸盐MSDS

L-犬尿氨酸硫酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

L-犬尿氨酸硫酸盐合成路线

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L-犬尿氨酸硫酸盐文献

Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts.

J. Inflamm. (Lond.) 8 , 25, (2011)

The kynurenine pathway (KP) is the main route of tryptophan degradation in the human body and generates several neuroactive and immunomodulatory metabolites. Altered levels of KP-metabolites have been...

The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine?

Cephalalgia 31 , 1029-1038, (2011)

In recent years the kynurenine family of compounds, metabolites of tryptophan, has become an area of intensive research because of its neuroactive properties. Two metabolites of this family have becom...

Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.

Infect. Immun. 79 , 4425-4437, (2011)

Gamma interferon (IFN-γ) induces expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial cells, the permissive cells for the obligate intracellular bact...

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