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司帕索霉素

司帕索霉素用途

稀疏霉素是稀疏链霉菌的代谢产物。Sparsomycin抑制真核细胞和细菌中的蛋白质合成。Sparsomycin抑制核糖体PTC的翻译延伸[1]。

司帕索霉素名称

[ CAS 号 ]:
1404-64-4

[ 中文名 ]:
司帕索霉素

[ 英文名 ]:
Sparsomycin

[中文别名 ]:

司帕霉素

[英文别名 ]:

Sparsomycin from Streptomyces sparsogenes
sparsamycin

司帕索霉素生物活性

[ 描述 ]:

稀疏霉素是稀疏链霉菌的代谢产物。Sparsomycin抑制真核细胞和细菌中的蛋白质合成。Sparsomycin抑制核糖体PTC的翻译延伸[1]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Codjo H, et, al. COVID-19: Mechanisms of the Antiviral Activities of Selective Antibiotics Targeting the Human 80S Ribosome. 2021;15:38-52.

[2]. Lazaro E, et, al. Interaction of the antibiotic sparsomycin with the ribosome. Antimicrob Agents Chemother. 1991 Jan;35(1):10-3.

司帕索霉素物理化学性质

[ 密度 ]:
1.466g/cm3

[ 分子式 ]:
C₁₃H₁₉N₃O₅S₂

[ 分子量 ]:
361.44

[ 精确质量 ]:
361.07700

[ PSA ]:
176.63000

[ LogP ]:
0.18770

[ 折射率 ]:
1.656

司帕索霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG5850000

CHEMICAL NAME :: Sparsomycin

CAS REGISTRY NUMBER :: 1404-64-4

LAST UPDATED :: 199504

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C13-H19-N3-O5-S2

MOLECULAR WEIGHT :: 361.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 20 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

司帕索霉素安全信息

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
28

[ 安全声明 (欧洲) ]:
28-36/37-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2