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邻氨基苯甲酸甲酯

邻氨基苯甲酸甲酯用途

邻氨基苯甲酸甲酯是一种植物香料提取物,是一种群体感应抑制剂和抗sobria气单胞菌生物膜剂。邻氨基苯甲酸甲酯已广泛用于食品加工业中食用香料和食品添加剂的制备[1]。

邻氨基苯甲酸甲酯名称

[ CAS 号 ]:
134-20-3

[ 中文名 ]:
氨茴酸甲酯

[ 英文名 ]:
Methyl 2-aminobenzoate

[中文别名 ]:

[英文别名 ]:

nerolioil,artifical
1-aminobenzene-2-carboxylic acid methyl ester
EINECS 205-132-4
2-Aminobenzoic Acid Methyl Ester
Carbomethoxyaniline
FEMA 2682
Methyl anthranylate
methyl o-amino-benzoate
methyl anthranlate
Methyl anthanilate

邻氨基苯甲酸甲酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

0.5μL/mL邻氨基苯甲酸甲酯可明显减少生物膜形成(51.44%)、摆动运动(74.86%)、群集运动(71.63%)、蛋白酶活性(43.08%)和酰基高丝氨酸内酯(AHL)的产生。邻氨基苯甲酸甲酯可能抑制A中的群体感应(QS)系统。sobria通过干扰AHL的生物合成以及与受体蛋白的竞争性结合[1]。

[参考文献]

[1]. Tingting Li, et al. Methyl anthranilate: A novel quorum sensing inhibitor and anti-biofilm agent against Aeromonas sobria. Food Microbiol. 2020 Apr;86:103356.

邻氨基苯甲酸甲酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
256.0±0.0 °C at 760 mmHg

[ 熔点 ]:
24 °C(lit.)

[ 分子式 ]:
C₈H₉NO₂

[ 分子量 ]:
151.163

[ 闪点 ]:
104.4±0.0 °C

[ 精确质量 ]:
151.063324

[ PSA ]:
52.32000

[ LogP ]:
2.04

[ 外观性状 ]:
淡黄色至暗液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.566

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
slightly soluble

邻氨基苯甲酸甲酯MSDS

邻氨基苯甲酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB3325000

CHEMICAL NAME :: Anthranilic acid, methyl ester

CAS REGISTRY NUMBER :: 134-20-3

BEILSTEIN REFERENCE NO. :: 0606965

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H9-N-O2

MOLECULAR WEIGHT :: 151.18

WISWESSER LINE NOTATION :: ZR BVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2910 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2780 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 34800 mg/kg

SEX/DURATION :: male 8 day(s) pre-mating female 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 23 mg/disc

REFERENCE :: OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975- Volume(issue)/page/year: 34,267,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1207 No. of Facilities: 174 (estimated) No. of Industries: 3 No. of Occupations: 17 No. of Employees: 2956 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1207 No. of Facilities: 7048 (estimated) No. of Industries: 66 No. of Occupations: 71 No. of Employees: 104513 (estimated) No. of Female Employees: 49243 (estimated)

邻氨基苯甲酸甲酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
CB3325000

[ 海关编码 ]:
2922499990

邻氨基苯甲酸甲酯合成路线

邻氨基苯甲酸甲酯上下游产品

邻氨基苯甲酸甲酯上游产品

邻氨基苯甲酸甲酯下游产品

邻氨基苯甲酸甲酯制备

1.在自然界，邻氨基苯甲酸甲酯存在于塔花油、橙花油、依兰依兰、茉莉油、晚香玉油等中。工业制造一般由邻氨基苯甲酸与甲醇酯化得到。将邻氨基苯甲酸的甲醇溶液加热到65℃，滴加硫酸，在75℃反应生成邻氨基苯甲酸甲酯的硫酸盐。然后用氢氧化钠溶液中和析出邻氨基苯甲酸甲酯。用甲苯萃取，洗涤甲苯萃取液并蒸去甲苯后，将粗制的邻氨基苯甲酸甲酯在存在碳酸钠的条件下进行减压精馏，将成品馏分冷至12-15℃以下，即析出邻氨基苯甲酸甲酯。另一种制法是由苯酐经氨化、降解、酯化而得到本品。

2.由邻氨基苯甲酸与甲醇在酸性条件下酯化，经碱中和制得。或由苯酐经氨化、降解、酯化制得。

3. 烟草：BU，14。

邻氨基苯甲酸甲酯海关

[ 海关编码 ]: 2922439000

[ 中文概述 ]:
2922439000. 邻氨基苯甲酸(氨茴酸)盐. 增值税率:17.0%. 退税率:9.0%. 监管条件:23(两用物项和技术进口许可证,两用物项和技术出口许可证). 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922439000 anthranilic acid salts。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

邻氨基苯甲酸甲酯文献

Palatability of bird repellents to Rattus norvegicus.

Pest Manag. Sci. 57(7) , 615-9, (2001)

The palatability to captive, mostly laboratory-bred, Norway rats (Rattus norvegicus) of cereal-based baits containing 0.02 g kg-1 brodifacoum, with and without bird-repellent additives, was compared i...

Synthesis and antibacterial activity of novel 4-chloro-2-mercaptobenzenesulfonamide derivatives.

J. Enzyme Inhib. Med. Chem. 28(1) , 41-51, (2013)

Few series of novel 4-chloro-2-mercaptobenzenesulfonamides have been synthesized by the reactions of N-(benzenesulfonyl)cyanamide potassium salts 7-15 with corresponding hydrazinecarbodithioic acid es...

High-performance liquid chromatographic determination of methyl anthranilate, hydroxymethylfurfural and related compounds in honey.

J. Chromatogr. A. 917(1-2) , 95-103, (2001)

A high-performance liquid chromatographic method for determining 5-hydroxymethyl-2-furaldehyde (hydroxymethylfurfural), 2-furaldehyde (furfural), furan-2-carboxylic acid (2-furoic acid), furan-3-carbo...

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