司盘80_MSDS_用途_密度_司盘80CAS号【1338-43-8】

山梨醇单油酸酯是一种具有独特分子结构的可再生多元醇,用于开发和设计生物基水性聚氨酯(WPU),具有多功能性和优异的机械性能。山梨醇单油酸酯可用作赋形剂,如非离子表面活性剂、乳化剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用辅料也会影响联合给药药物的吸收、分布、代谢和消除(ADME)过程[1][2]。

[ 描述 ]:

山梨醇单油酸酯是一种具有独特分子结构的可再生多元醇,用于开发和设计生物基水性聚氨酯(WPU),具有多功能性和优异的机械性能。山梨醇单油酸酯可用作赋形剂,如非离子表面活性剂、乳化剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用辅料也会影响联合给药药物的吸收、分布、代谢和消除(ADME)过程[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Deng H, et al. UV resistance, anticorrosion and high toughness bio-based waterborne polyurethane enabled by a Sorbitan monooleate[J]. Chemical Engineering Journal, 2022, 446: 137124.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
579.3±50.0 °C at 760 mmHg

[ 熔点 ]:
0.986ºC

[ 分子式 ]:
C₂₄H₄₄O₆

[ 分子量 ]:
428.603

[ 闪点 ]:
186.2±23.6 °C

[ 精确质量 ]:
428.313782

[ PSA ]:
96.22000

[ LogP ]:
7.14

[ 外观性状 ]:
黄色至棕色液体

[ 蒸汽压 ]:
0.0±3.6 mmHg at 25°C

[ 折射率 ]:
1.506

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG2932400

CHEMICAL NAME :: Sorbitan, monooleate

CAS REGISTRY NUMBER :: 1338-43-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C24-H44-O6

MOLECULAR WEIGHT :: 428.68

WISWESSER LINE NOTATION :: T5OTJ BV1OV8U9 CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 254 gm/kg/6W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - pigmented or nucleated red blood cells

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 100 ppm

REFERENCE :: BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,630,1971 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83475 No. of Facilities: 11289 (estimated) No. of Industries: 95 No. of Occupations: 73 No. of Employees: 71826 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83475 No. of Facilities: 14163 (estimated) No. of Industries: 127 No. of Occupations: 106 No. of Employees: 200724 (estimated) No. of Female Employees: 58462 (estimated)

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
T+

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
WG2932400

[ 海关编码 ]:
34021300

1. 将88 kg山梨糖醇投入反应釜中，减压脱水，脱水完毕后，压入精制好的油酸130 kg，氢氧化钠适量（作催化剂）。开搅拌、抽真空、缓慢升温，在200～210℃下反应6 h。取样测酸值，当酸值为6～7时，酯化反应完毕。冷却降温，静置24 h，静置后分上下两层，下层为黑色胶状物，分离弃之。将上层澄清液压入脱色釜内，加热至65℃左右用活性炭脱色，在80～85℃脱色1 h。过滤，滤液在真空下脱水5h得成品。

2. 失水山梨醇与油酸进行酯化反应制得。

[ 海关编码 ]: 34021300

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