吲哚并[2,1-b]喹唑啉-6,12-二酮

吲哚并[2,1-b]喹唑啉-6,12-二酮用途

Tryptanthrin 是一种有效的口服活性细胞内 Leukotriene (LT) biosynthesis 抑制剂。 Tryptanthrin 抑制人全血中Leukotriene 的形成 (IC50 = 10 µM),并降低大鼠胸膜炎模型中的 LTB4 水平。

吲哚并[2,1-b]喹唑啉-6,12-二酮名称

[ CAS 号 ]:
13220-57-0

[ 中文名 ]:
色胺酮

[ 英文名 ]:
Tryptanthrine

[中文别名 ]:

[英文别名 ]:

Tryptanthrin
MFCD00012073
indolo[2,1-b]quinazoline-6,12-dione

吲哚并[2,1-b]喹唑啉-6,12-二酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[ 靶点 ]

IC50: 10 µM (LT formation in human whole blood)[1]

[参考文献]

[1]. Pergola C, et al. On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo.Br J Pharmacol. 2012 Feb;165(3):765-76.

吲哚并[2,1-b]喹唑啉-6,12-二酮物理化学性质

[ 密度 ]:
1.45g/cm3

[ 沸点 ]:
469.3ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₈N₂O₂

[ 分子量 ]:
248.23600

[ 闪点 ]:
237.7ºC

[ 精确质量 ]:
248.05900

[ PSA ]:
51.96000

[ LogP ]:
1.93010

[ 蒸汽压 ]:
5.55E-09mmHg at 25°C

[ 折射率 ]:
1.762

[ 储存条件 ]:
室温

吲哚并[2,1-b]喹唑啉-6,12-二酮安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

吲哚并[2,1-b]喹唑啉-6,12-二酮合成路线

详细合成路线

吲哚并[2,1-b]喹唑啉-6,12-二酮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吲哚并[2,1-b]喹唑啉-6,12-二酮文献

Tryptanthrin ameliorates atopic dermatitis through down-regulation of TSLP.

Arch. Biochem. Biophys. 542 , 14-20, (2014)

Atopic dermatitis (AD) is a common skin disease that greatly worsens quality of life. Thymic stromal lymphopoietin (TSLP) plays a decisive role in the development of AD. The purpose of this study is t...

Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular endothelial cells.

J. Ethnopharmacol. 174 , 474-81, (2015)

Indigo naturalis has been used to treat inflammatory diseases and dermatosis, including psoriasis, since thousands of years in China. It has been proven effective in our previous clinical studies on t...

Kourokhitin, a potential drug containing two active substances.

Dokl. Biochem. Biophys. 426 , 131-3, (2009)

更多文献