噻虫胺-D3

噻虫胺-D3用途

Clothianidin-d3是氘标记的Clothinidin。

噻虫胺-D3名称

[ CAS 号 ]:
1262776-24-8

[ 中文名 ]:
噻虫胺-D3

[ 英文名 ]:
Clothianidine-d3

[英文别名 ]:

Clothianidin-d3
Clothianidine-d3

噻虫胺-D3生物活性

[ 描述 ]:

Clothianidin-d3是氘标记的Clothinidin。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

噻虫胺-D3物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
435.2±55.0 °C at 760 mmHg

[ 分子式 ]:
C₆H₅ClD₃N₅O₂S

[ 分子量 ]:
252.697

[ 闪点 ]:
217.0±31.5 °C

[ 精确质量 ]:
252.027557

[ PSA ]:
123.37000

[ LogP ]:
-0.15

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.709

噻虫胺-D3MSDS

详细MSDS(安全技术说明书)

噻虫胺-D3安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H410

[ 警示性声明 ]:
P273-P501

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

噻虫胺-D3文献

Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 85-94, (2014)

A rapid and sensitive analytical method was developed for simultaneous determination of eight neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, ...

Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics.

PLoS ONE 11 , e0146335, (2016)

Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested tha...

Field-scale examination of neonicotinoid insecticide persistence in soil as a result of seed treatment use in commercial maize (corn) fields in southwestern Ontario.

Environ. Toxicol. Chem. 35 , 295-302, (2016)

Neonicotinoid insecticides, especially as seed treatments, have raised concerns about environmental loading and impacts on pollinators, biodiversity, and ecosystems. The authors measured concentration...

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