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盐酸赛洛唑啉

盐酸赛洛唑啉用途

Xylometazoline盐酸盐是α-肾上腺素受体激动剂,为鼻血管收缩药。

盐酸赛洛唑啉名称

[ CAS 号 ]:
1218-35-5

[ 中文名 ]:
盐酸赛洛唑啉

[ 英文名 ]:
Xylometazoline hydrochloride

[中文别名 ]:

溴化半胆碱

[英文别名 ]:

Xylometazoline HCl
Xylometazoline hydrochloride
MFCD00238707
EINECS 214-936-4
Xylometazoline (hydrochloride)

盐酸赛洛唑啉生物活性

[ 描述 ]:

Xylometazoline盐酸盐是α-肾上腺素受体激动剂,为鼻血管收缩药。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 心血管疾病

[参考文献]

[1]. Eccles, R., et al., The nasal decongestant effect of xylometazoline in the common cold. Am J Rhinol, 2008. 22(5): p. 491-6.

[2]. Haenisch, B., et al., Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol, 2010. 24(6): p. 729-39.

[相关活性小分子]

盐酸赛洛唑啉物理化学性质

[ 沸点 ]:
394.2ºC at 760 mmHg

[ 熔点 ]:
131-133ºC

[ 分子式 ]:
C₁₆H₂₅ClN₂

[ 分子量 ]:
280.836

[ 闪点 ]:
192.2ºC

[ 精确质量 ]:
280.170624

[ PSA ]:
24.39000

[ LogP ]:
3.71150

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
4.56E-06mmHg at 25°C

[ 储存条件 ]:
室温，密封，干燥

盐酸赛洛唑啉MSDS

详细MSDS(安全技术说明书)

盐酸赛洛唑啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ2390000

CHEMICAL NAME :: 2-Imidazoline, 2-(4-tert-butyl-2,6-dimethylbenzyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 1218-35-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C16-H24-N2.Cl-H

MOLECULAR WEIGHT :: 280.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,555,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 43 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,555,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,555,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,555,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 53 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,555,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,555,1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1080 mg/kg/6W-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in cell count (unspecified) Endocrine - adrenal cortex hyperplasia

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,555,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2340 mg/kg/26W-I

TOXIC EFFECTS :: Endocrine - adrenal cortex hyperplasia Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,555,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4782 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated) No. of Female Employees: 14 (estimated)

盐酸赛洛唑啉安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
NJ2390000

盐酸赛洛唑啉文献

[Nasal decongestants and eye drops: keep out of children's reach!].

Perspect. Infirm. 10(2) , 63, (2013)

Intranasal topical local anesthetic and decongestant for flexible nasendoscopy in children: a randomized, double-blind, placebo-controlled trial.

JAMA Otolaryngol. Head Neck Surg. 139(12) , 1301-5, (2013)

To our knowledge, the present study is the first double-blind, randomized, placebo-controlled trial in children to compare nasal preparation sprays administered before flexible nasendoscopy with place...

Prognostic value of anterior rhinomanometry in diode laser turbinoplasty.

Arch. Otolaryngol. Head Neck Surg. 136(10) , 1015-9, (2010)

To identify objective criteria predicting the success of diode laser-assisted turbinoplasty.Prospective before-and-after trial with follow-up of 8 weeks.Outpatient department of a tertiary referral ce...

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