邻苯二甲酸二辛酯

邻苯二甲酸二辛酯用途

【用途一】
本品可与聚氯乙烯、氯乙烯-乙酸乙烯共聚物、聚乙烯醇缩丁醛、乙酸丁酸纤维素、硝酸纤维素、乙基纤维素、聚甲基丙烯酸甲酯、聚苯乙烯等树脂相容，但与乙酸纤维素、聚乙酸乙烯酯不相容。本品的增塑效率与DOP相同，但耐寒性、耐候性、耐挥发性及对增塑糊粘度的稳定性均比DOP好，电绝缘性比DOP稍差。因价格高，应用不广泛。本品属无毒增塑剂，可用于制作食品包装材料。本品还用作溶剂和气相色谱固定液。
【用途二】
气相色谱固定液，选择性保留和分离芳香族化合物、不饱和化合物以及各种含氧化合物(醇、醛、酮、酯等)。溶剂。增塑剂。
【用途三】
用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。

邻苯二甲酸二辛酯名称

[ CAS 号 ]:
117-84-0

[ 中文名 ]:
邻苯二甲酸二正辛酯

[ 英文名 ]:
Dioctyl phthalate

[中文别名 ]:

[英文别名 ]:

1,2-Benzenedicarboxylic acid, dioctyl ester
Bis(2-octyl) phthalate
MFCD00015292
Phthalic acid di-n-octyl ester
o-Benzenedicarboxylic acid, dioctyl ester
EINECS 204-214-7
di-n-octylphthalate
phthalic acid dioctyl ester
Dioctyl phthalate
Benzenedicarboxylic acid di-n-octyl ester

邻苯二甲酸二辛酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
416.4±13.0 °C at 760 mmHg

[ 熔点 ]:
25ºC

[ 分子式 ]:
C₂₄H₃₈O₄

[ 分子量 ]:
390.556

[ 闪点 ]:
222.3±9.3 °C

[ 精确质量 ]:
390.277008

[ PSA ]:
52.60000

[ LogP ]:
9.08

[ 外观性状 ]:
透明液体带有一种温和气味

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.490

[ 储存条件 ]:
包装完整、轻装轻放,库房通风、远离明火、高温、与氧化剂分开存放

[ 水溶解性 ]:
水溶性：不溶；水溶解度：3 mg/l 25 °C

邻苯二甲酸二辛酯MSDS

详细MSDS(安全技术说明书)

邻苯二甲酸二辛酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI1925000

CHEMICAL NAME :: Phthalic acid, dioctyl ester

CAS REGISTRY NUMBER :: 117-84-0

BEILSTEIN REFERENCE NO. :: 1915994

LAST UPDATED :: 199710

DATA ITEMS CITED :: 25

MOLECULAR FORMULA :: C24-H38-O4

MOLECULAR WEIGHT :: 390.62

WISWESSER LINE NOTATION :: 8OVR BVO8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,390,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,390,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 47 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 39,635,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >50 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 61,51,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6513 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 17(11),51,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 28,667,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year: 2,1906,1963 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26850 mg/kg/5D-I

TOXIC EFFECTS :: Endocrine - other changes Immunological Including Allergic - decrease in humoral immune response Immunological Including Allergic - decreased immune response

REFERENCE :: INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963- Volume(issue)/page/year: 25,97,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25200 mg/kg/21D-C

TOXIC EFFECTS :: Liver - fatty liver degeneration Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 77,116,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23 gm/kg/11W-C

TOXIC EFFECTS :: Liver - fatty liver degeneration Liver - other changes

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 8,38,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 54 gm/kg/90D-C

TOXIC EFFECTS :: Endocrine - other changes Blood - changes in spleen

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 23,315,1985 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 5 gm/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 61,51,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 78 gm/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB85-220143

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 78240 mg/kg

SEX/DURATION :: female 6-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 7,29,1987 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 54,1,1975 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,3,1973 TOXICOLOGY REVIEW ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (93),1,1975 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5673 No. of Facilities: 1177 (estimated) No. of Industries: 13 No. of Occupations: 16 No. of Employees: 10393 (estimated) No. of Female Employees: 1434 (estimated)

邻苯二甲酸二辛酯安全信息

[ 危害声明 ]:
H413

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
60-61

[ 安全声明 (欧洲) ]:
S23-S24/25

[ 危险品运输编码 ]:
UN 3082

[ WGK德国 ]:
2

[ RTECS号 ]:
TI1925000

[ 海关编码 ]:
2917349000

邻苯二甲酸二辛酯合成路线

详细合成路线

邻苯二甲酸二辛酯上下游产品

邻苯二甲酸二辛酯上游产品

邻苯二甲酸二辛酯下游产品

邻苯二甲酸二辛酯制备

1.由苯酐与正辛醇在常压下酯化生产将苯酐、正辛醇、苯、硫酸加入反应釜，搅拌下慢慢加热升温，至苯及水开始蒸出。苯水混合气经冷凝器冷凝后，由苯水分离器分出水分，苯回流至釜内继续蒸发带水。当没有水带出时，酯化反应完成，然后回收苯，冷却、碱洗、水洗、干燥、减压蒸馏，即得成品。

2.由苯酐与正辛醇减压下酯的生产分为间歇法和连续法两种。

（1）间歇法适用于小批量生产。物料配比为苯酐∶辛醇＝1∶2（质量比），硫酸为总物料的0.25%～0.3%，酯化时加入的活性炭为总物料量的0.1%～0.3%。酯化温度为150℃，酯化时真空度0.093MPa左右，酯化时间约为3h。粗酯洗涤的热水温度为80～85℃。蒸馏回收辛醇的温度为130～140℃，真空度不低于0.093MPa。成品若要求为优质品，需将脱醇后的粗酯进行蒸馏，再经压滤。

（2）连续法适于大规模生产。首先进行单酯化，物料配比为苯酐∶辛醇＝1∶1.6（质量比），硫酸用量为总量的0.5%，反应温度为120℃，单酯化反应生成透明均一的液体。第二步酯化在塔中进行，单酯液连续进入塔内，在130～150℃、真空度大于0.093MPa下连续酯化。粗酯以1/5体积的50℃水进行洗涤，以2%～3%的纯碱液于60～70℃下连续中和；中和后的粗酯液以1∶1体积的70～80℃的水洗涤。然后加入活性炭0.1%，在真空度0.097MPa、温度为150℃的条件下连续脱醇。脱醇后酯液在100～120℃下压滤，得成品。

精制方法：含有游离的酸、醇和邻苯二甲酸一辛酯等杂质。精制时用稀的氢氧化钠溶液洗涤，无水碳酸钾或硫酸钠干燥后减压蒸馏。

3.对甲苯磺酸催化法　在装有温度计、分水器、回流冷凝管的三口烧瓶中依次加入0.05mol的邻苯二甲酸、0.15mol正辛醇、1g对甲苯磺酸和0.1g活性炭，混合均匀，分水器中加入正辛醇直至与支管口相平，用电子调温电热套加热，待邻苯二甲酸固体消失后，迅速升温至160℃，控制反应温度在160～180℃，回流分水1h。反应结束后，将反应液冷至室温，用等体积饱和食盐水洗涤2～3次，使之呈中性，粗产物中加入少量活性炭，先在水泵减压下蒸去正辛醇，再用油泵减压蒸馏，收集224～234℃的馏分，得淡黄色透明微有气味的油状液体。

邻苯二甲酸二辛酯海关

[ 海关编码 ]: 2917349000

[ 中文概述 ]:
2917349000 其他邻苯二甲酸酯。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917349000 other esters of orthophthalic acid。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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