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全反式-β-阿林胡萝卜醛

全反式-β-阿林胡萝卜醛用途

β-Apo-8'-carotenal (Apocarotenal) 是一种维生素原 A 类胡萝卜素,是大鼠CYP1A1 和 CYP1A2 的诱导剂。 β-Apo-8'-carotenal 存在于许多水果和蔬菜中。

全反式-β-阿林胡萝卜醛名称

[ CAS 号 ]:
1107-26-2

[ 中文名 ]:
β-阿朴胡萝卜素醛

[ 英文名 ]:
β-Apo-8'-carotenal

[中文别名 ]:

[英文别名 ]:

8'-Apo-β-carotenal
Apocarotenal
all-trans-8'-apo-β-carotenal
C.I. Food Orange 6
EINECS 214-171-6
8'-apo-beta,psi-caroten-8'-al
β-Apocarotenal
trans-β-Apo-8′-carotenal
all-trans-β-Apo-8'-carotenal
trans-β-Apo-8'-carotenal

全反式-β-阿林胡萝卜醛生物活性

[ 描述 ]:

β-Apo-8'-carotenal (Apocarotenal) 是一种维生素原 A 类胡萝卜素,是大鼠CYP1A1 和 CYP1A2 的诱导剂。 β-Apo-8'-carotenal 存在于许多水果和蔬菜中。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

[ 靶点 ]

CYP1A1

CYP1A2

[参考文献]

[1]. Gradelet S, et al.beta-Apo-8'-carotenal, but not beta-carotene, is a strong inducer of liver cytochromes P4501A1 and 1A2 in rat.Xenobiotica. 1996 Sep;26(9):909-19.

全反式-β-阿林胡萝卜醛物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
575.7±19.0 °C at 760 mmHg

[ 熔点 ]:
138-141ºC

[ 分子式 ]:
C₃₀H₄₀O

[ 分子量 ]:
416.638

[ 闪点 ]:
273.8±13.8 °C

[ 精确质量 ]:
416.307922

[ PSA ]:
17.07000

[ LogP ]:
9.82

[ 外观性状 ]:
suspension (oily)

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.553

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
chloroform: 1 mg/mL, clear to very faintly turbid, intense red-orange

全反式-β-阿林胡萝卜醛MSDS

全反式-β-阿林胡萝卜醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CD9115000

CHEMICAL NAME :: 8'-Apo-beta,psi-carotenal

CAS REGISTRY NUMBER :: 1107-26-2

BEILSTEIN REFERENCE NO. :: 2064131

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C30-H40-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 38B,34,1966 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 85 gm/kg/34W-I

TOXIC EFFECTS :: Related to Chronic Data - changes in testicular weight

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 38B,34,1966

全反式-β-阿林胡萝卜醛安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
CD9115000

全反式-β-阿林胡萝卜醛合成路线

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全反式-β-阿林胡萝卜醛制备

1.锰酸钾氧化β-胡萝卜素而得。

全反式-β-阿林胡萝卜醛文献

The formation, occurrence, and function of β-apocarotenoids: β-carotene metabolites that may modulate nuclear receptor signaling.

Am. J. Clin. Nutr. 96(5) , 1189S-92S, (2012)

β-Carotene is the major dietary source of provitamin A. Central cleavage of β-carotene yields 2 molecules of retinal followed by further oxidation to retinoic acid. Eccentric cleavage of β-carotene oc...

Structural basis of carotenoid cleavage: from bacteria to mammals.

Arch. Biochem. Biophys. 539(2) , 203-13, (2013)

Carotenoids and their metabolic derivatives serve critical functions in both prokaryotic and eukaryotic cells, including pigmentation, photoprotection and photosynthesis as well as cell signaling. The...

beta-Apo-8'-carotenal, but not beta-carotene, is a strong inducer of liver cytochromes P4501A1 and 1A2 in rat.

Xenobiotica 26(9) , 909-19, (1996)

1. The catalytic activities of several phase I and II xenobiotic-metabolizing enzymes and their immunochemical detection have been investigated in liver microsomes and cytosol of the male rat, which h...

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