四甲基乙二胺(TEMED)

四甲基乙二胺(TEMED)用途

【用途一】
用作生化试剂
【用途二】
是极性非质子溶剂，也用于制备烯基炔化物等有机试剂
【用途三】
四甲基乙二胺（110-18-9）主要应用于水处理剂，生化试剂，环氧树脂交联剂，也可以用做季胺类中间体原料。
【用途四】
用于聚丙烯酰胺凝胶的制备。

四甲基乙二胺(TEMED)名称

[ CAS 号 ]:
110-18-9

[ 中文名 ]:
四甲基乙二胺

[ 英文名 ]:
TMEDA

[中文别名 ]:

[英文别名 ]:

N,N,N′,N′ tetramethylethylenediamine
Tetrameen
EINECS 203-744-6
N,N,N',N'-Tetramethylethylenediamine
N,N,N`,N`-Tetramethylethylenediamine
1,2-Bis(dimethylamino)ethane,TEMED,TMEDA
Kaolizer 11
1,2-Bis(dimethylamino)ethane
N,N,N,N-Tetramethylethylenediamine
tetramethyldiaminoethane

四甲基乙二胺(TEMED)物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
121.0±0.0 °C at 760 mmHg

[ 熔点 ]:
−55 °C(lit.)

[ 分子式 ]:
C₆H₁₆N₂

[ 分子量 ]:
116.205

[ 闪点 ]:
10.0±0.0 °C

[ 精确质量 ]:
116.131348

[ PSA ]:
6.48000

[ LogP ]:
0.30

[ 外观性状 ]:
无色液体淡氨的气味

[ 蒸汽压 ]:
14.9±0.2 mmHg at 25°C

[ 折射率 ]:
1.438

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, copper, mercury.

[ 水溶解性 ]:
miscible

四甲基乙二胺(TEMED)MSDS

四甲基乙二胺(TEMED)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KV7175000

CHEMICAL NAME :: Ethylenediamine, N,N,N',N'-tetramethyl-

CAS REGISTRY NUMBER :: 110-18-9

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C6-H16-N2

MOLECULAR WEIGHT :: 116.24

WISWESSER LINE NOTATION :: 1N1&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,63,1948

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 268 mg/kg

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 15,19,1995

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1318 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - ataxia Behavioral - irritability

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 8,249,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 630 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 28(6),55,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 15,19,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 ppm/6H/11D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536165 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1174 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 66 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1174 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

四甲基乙二胺(TEMED)安全信息

[ 符号 ]:

GHS02, GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H314-H332

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R11;R20/22;R34

[ 安全声明 (欧洲) ]:
S16-S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2372 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
KV7175000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2921219000

四甲基乙二胺(TEMED)合成路线

四甲基乙二胺(TEMED)上下游产品

四甲基乙二胺(TEMED)上游产品

四甲基乙二胺(TEMED)下游产品

四甲基乙二胺(TEMED)制备

在安装了冷凝器、搅拌器和滴液漏斗的12升三颈园底烧瓶中盛4060毫升90%甲酸，在搅拌下从滴掖漏斗中慢慢加入1040克 (17.3摩尔)乙二胺，然后较快一些地加入5960毫升37%的甲醛溶液。从溶液中均匀地逸出二氧化碳表明反应正在进行，当开始迅速放出气泡的阶段平息后，加热回流48小时，趁仍然沸腾时，小心地用1.0升浓硫酸处理反应混合物使胺成为盐。蒸掉过量的甲醛、甲酸和水。在收集了5600毫升蒸馏液之后，残余物开始发泡，加入新的用900克氢氧化钠配成的50%水溶液，大约要蒸出1升的胺产物。残余物用浓氢氧化钾水溶液处理可以盐析出更多的胺。合并所得的胺，用粒状氢氧化钾干燥，与钠一道蒸馏，即得N,N,N'N'-四甲基乙二胺。

四甲基乙二胺(TEMED)海关

[ 海关编码 ]: 2921290000

[ 中文概述 ]:
2921290000. 其他无环多胺及其衍生物及它们的盐. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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