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12-羟基硬脂酸

12-羟基硬脂酸用途

12-羟基硬脂酸是一种结构简单、成本低廉的低分子量有机凝胶剂,其金属盐和衍生物在许多重要应用中发挥了作用[1][2]。

12-羟基硬脂酸名称

[ CAS 号 ]:
106-14-9

[ 中文名 ]:
12-羟基十八酸

[ 英文名 ]:
12-hydroxyoctadecanoic acid

[中文别名 ]:

12-羟基硬脂酸

[英文别名 ]:

MFCD00004592
DL-12-hydroxystearic acid
Octadecanoic acid, 12-hydroxy-
EINECS 203-366-1
UNII:933ANU3H2S
12-Hydroxyoctadecanoic acid
DL-12-hydroxy stearic acid
12-Hydroxystearic acid

12-羟基硬脂酸生物活性

[ 描述 ]:

12-羟基硬脂酸是一种结构简单、成本低廉的低分子量有机凝胶剂,其金属盐和衍生物在许多重要应用中发挥了作用[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

由于12-羟基硬脂酸(12HSA)作为凝胶剂的有效性和在润滑剂中的实用性,人们对其及其衍生物进行了详细的研究[1]。

[参考文献]

[1]. Gordon R, et al. Aggregation of 12-Hydroxystearic Acid and Its Lithium Salt in Hexane: Molecular Dynamics Simulations. J Phys Chem B. 2016;120(29):7164-7173.

12-羟基硬脂酸物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
436.3±18.0 °C at 760 mmHg

[ 熔点 ]:
80-81ºC

[ 分子式 ]:
C₁₈H₃₆O₃

[ 分子量 ]:
300.477

[ 闪点 ]:
231.8±17.7 °C

[ 精确质量 ]:
300.266449

[ PSA ]:
57.53000

[ LogP ]:
6.03

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.468

[ 储存条件 ]:
−20°C

12-羟基硬脂酸MSDS

12-羟基硬脂酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WI3850000

CHEMICAL NAME :: Stearic acid, 12-hydroxy-

CAS REGISTRY NUMBER :: 106-14-9

BEILSTEIN REFERENCE NO. :: 1726730

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H36-O3

MOLECULAR WEIGHT :: 300.54

WISWESSER LINE NOTATION :: QV10YQ6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg/40W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 700 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 122,87,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1187 No. of Facilities: 5682 (estimated) No. of Industries: 85 No. of Occupations: 50 No. of Employees: 71848 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1187 No. of Facilities: 5607 (estimated) No. of Industries: 44 No. of Occupations: 38 No. of Employees: 52609 (estimated) No. of Female Employees: 4374 (estimated)

12-羟基硬脂酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
WI3850000

[ 海关编码 ]:
2942000000

12-羟基硬脂酸合成路线

12-羟基硬脂酸上下游产品

12-羟基硬脂酸上游产品

12-羟基硬脂酸下游产品

12-羟基硬脂酸制备

【方法一】
由蓖麻油在镍-铝催化剂存在下，于185℃和5MPa条件下加氢，反应产物经皂化、酸解即得产品。

12-羟基硬脂酸海关

[ 海关编码 ]: 2918199090

[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

12-羟基硬脂酸文献

Novel semisolid SNEDDS based on PEG-30-di-(polyhydroxystearate): Progesterone incorporation and in vitro digestion.

Int. J. Pharm. 486 , 77-87, (2015)

The aim of this work is to study the digestibility of PEG-30-di-(polyhydroxystearate) (Cithrol(®) DPHS) and its semisolid novel self-nanoemulsifying drug delivery systems (SNEDDS). Furthermore, the SN...

Development of multifunctional lipid nanocapsules for the co-delivery of paclitaxel and CpG-ODN in the treatment of glioblastoma.

Int. J. Pharm. 495 , 972-80, (2015)

In this work, multifunctional lipid nanocapsules (M-LNC) were designed to combine the activity of the cytotoxic drug paclitaxel (PTX) with the immunostimulant CpG. This nanosystem, consisting of modif...

Core-shell structured gel-nanocarriers for sustained drug release and enhanced antitumor effect.

Int. J. Pharm. 484(1-2) , 163-71, (2015)

The present paper attempted to develop temperature-sensitive and core-shell structured gel-nanocarriers (gel-NCs) for paclitaxel (PTX) with 12-hydroxystearic acid (12-HSA) as an organic gelator, which...

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