己二酸二异辛酯

己二酸二异辛酯用途

【用途一】
用作多种树脂特别是聚氯乙烯和氯乙烯共聚物的耐寒增塑剂，也可用作航空润滑脂的原料
【用途二】
该品是聚氯乙烯的优良耐寒增塑剂，赋予制品优良的低温柔软性，并具有一定的光热稳定性和耐水性。在塑溶胶中，初期粘度低，粘度稳定性良好。常与DOP等主增塑剂并用于耐寒的农用薄膜、电线、薄板、人造革、户外用水管以及冷冻食品的包装薄膜。还可作为许多合成橡胶的低温增塑剂以及硝基纤维素、乙基纤维素等树脂的增塑剂。在实验室工作中用作气相色谱固定液。己二酸二（2-乙基己基）酯的毒性很低，对人的致死量大约为500000mg/kg，对大鼠口服LD50为3000-6000mg/kg，对皮肤及眼睛的刺激也很轻微。
【用途三】
气相色谱固定液(最高使用温度135℃，溶剂为乙醚)。增塑剂。溶剂。

己二酸二异辛酯名称

[ CAS 号 ]:
103-23-1

[ 中文名 ]:
己二酸二(2-乙基己)酯

[ 英文名 ]:
DEHA

[中文别名 ]:

[英文别名 ]:

Bis(2-ethylhexyl)adipat
Dioctyl Adipate
DEHA
Adipic Acid Dioctyl Ester
Adipic acid di(2-ethylhexyl) ester
Bis(2-ethylhexyl)adipate
Hexanedioic acid, bis(2-ethylhexyl) ester
EINECS 203-090-1
Di(2-ethylhexyl)adipate
di-(2-Ethylhexyl) adipate

己二酸二异辛酯物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
374.4±0.0 °C at 760 mmHg

[ 熔点 ]:
-67 °C

[ 分子式 ]:
C₂₂H₄₂O₄

[ 分子量 ]:
370.566

[ 闪点 ]:
168.9±17.4 °C

[ 精确质量 ]:
370.308319

[ PSA ]:
52.60000

[ LogP ]:
8.10

[ 外观性状 ]:
无色或淡黄色油性液体,带有特殊的气味

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.451

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents, water, nitrates.

[ 水溶解性 ]:
immiscible

己二酸二异辛酯MSDS

详细MSDS(安全技术说明书)

己二酸二异辛酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU9700000

CHEMICAL NAME :: Adipic acid, bis(2-ethylhexyl) ester

CAS REGISTRY NUMBER :: 103-23-1

BEILSTEIN REFERENCE NO. :: 1803774

LAST UPDATED :: 199806

DATA ITEMS CITED :: 35

MOLECULAR FORMULA :: C22-H42-O4

MOLECULAR WEIGHT :: 370.64

WISWESSER LINE NOTATION :: 4Y2&1OV4VO1Y4&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >50 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 16 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25200 mg/kg/3W-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 191 gm/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 168 gm/kg/14D-C

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 gm/kg/13W-C

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1038 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2163 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1048 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 15 gm/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 gm/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 400 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,257,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,257,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80276 No. of Facilities: 534 (estimated) No. of Industries: 19 No. of Occupations: 31 No. of Employees: 11847 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80276 No. of Facilities: 524 (estimated) No. of Industries: 15 No. of Occupations: 21 No. of Employees: 15636 (estimated) No. of Female Employees: 3628 (estimated)

己二酸二异辛酯安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H331-H370

[ 警示性声明 ]:
P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S26-S36-S45-S36/37

[ 危险品运输编码 ]:
UN 1230 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
AU9700000

[ 海关编码 ]:
29171290

己二酸二异辛酯合成路线

详细合成路线

己二酸二异辛酯上下游产品

己二酸二异辛酯上游产品

己二酸二异辛酯下游产品

己二酸二异辛酯制备

己二酸和辛醇按摩尔比1∶2.5的比例投入反应釜，加入己二酸质量0.1%的硫酸，搅拌下升温，抽真空。控制酯化温度120～130℃，真空度86.7～90.7kPa，反应时间2h。反应中加入活性炭，质量为己二酸质量的5%左右，用以吸附氧气和脱色。反应完成后的酯化液在60～65℃的温度下，用2%的液碱中和。静置分层。酯层再用60～65℃的温热水洗涤。分去水层后的粗酯进行减压蒸馏，在真空933kPa、150～160℃的条件下脱醇，回收辛醇。脱醇后的酯经压滤后得成品。若需进一步精制，可经高真空蒸馏，收集210℃，667Pa左右的馏分。

精制方法：含有游离的酸和醇等杂质。精制时用无水碳酸钾干燥后减压精馏。

己二酸二异辛酯海关

[ 海关编码 ]: 2917120090

[ 中文概述 ]:
2917120090. 己二酸及其盐和酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2917120090. adipic acid and its salts. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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