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硫氰酸 2-(3,4-二羟基苯基)-2-氧代乙酯

硫氰酸 2-(3,4-二羟基苯基)-2-氧代乙酯用途

BiP诱导剂X是免疫球蛋白重链结合蛋白(BiP)/GRP78的选择性诱导剂,是一种有效的内质网应激抑制剂。BiP诱导剂X优先诱导BiP,轻微诱导GRP94、钙网蛋白和C/EBP同源蛋白。BiP诱导剂X保护神经元免受内质网应激[1][2]。

硫氰酸 2-(3,4-二羟基苯基)-2-氧代乙酯名称

[ CAS 号 ]:
101714-41-4

[ 中文名 ]:
2-(3,4-二羟基苯基)-2-氧代硫氰酸乙酯 (9ci)

[ 英文名 ]:
BiP inducer X

[中文别名 ]:

硫氰酸,2-(3,4-二羟基苯基)-2-氧代乙基酯

[英文别名 ]:

BIX
1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone
2-(3,4-Dihydroxyphenyl)-2-oxoethyl thiocyanate
1-(3,4-Dihydroxy-phenyl)-2-thiocyanato-aethanon
Thiocyanicacid,3,4-dihydroxyphenacyl ester (6CI)
1-(3,4-dihydroxy-phenyl)-2-thiocyanato-ethanone
BiP inducer X

硫氰酸 2-(3,4-二羟基苯基)-2-氧代乙酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 神经疾病

[体外研究]

BiP诱导剂X(5 μM；0-12小时；SK-N-SH细胞)增加BiP蛋白[1]。BiP诱导剂X(BIX)对BiP的诱导是通过ATF6途径激活内质网应激反应元件(ERSE)[1]。BiP诱导剂X(5 μM；12小时；SK-N-SH细胞预处理可抑制内质网应激诱导的细胞死亡,包括抑制半胱天冬酶3/7和4的激活[1]。

[体内研究]

服用BiP诱导剂X可减少因脑梗死引起的损伤[1]。A 20 μg剂量的BiP诱导剂X可减少因MCA闭塞而在半影区诱导的内质网应激诱导的凋亡[1]。动物模型：雄性成年ddY小鼠,体重24-34 g(日本SLC)[1]剂量：20 μg(2 μl)给药：侧脑室内结果：显著增加BiP蛋白24的水平 h给药后,确认给药BIX在体内诱导BiP蛋白。

[参考文献]

[1]. Kudo T, et al. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008;15(2):364-375.

[2]. Yoo SA, et al. A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis. J Exp Med. 2012;209(4):871-886.

硫氰酸 2-(3,4-二羟基苯基)-2-氧代乙酯物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
517.1±45.0 °C at 760 mmHg

[ 熔点 ]:
127 °C

[ 分子式 ]:
C₉H₇NO₃S

[ 分子量 ]:
209.22

[ 闪点 ]:
266.5±28.7 °C

[ 精确质量 ]:
209.014664

[ PSA ]:
106.62000

[ LogP ]:
1.53

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.665

[ 储存条件 ]:
2-8°C，密封，干燥

硫氰酸 2-(3,4-二羟基苯基)-2-氧代乙酯MSDS

硫氰酸 2-(3,4-二羟基苯基)-2-氧代乙酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

硫氰酸 2-(3,4-二羟基苯基)-2-氧代乙酯合成路线

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硫氰酸 2-(3,4-二羟基苯基)-2-氧代乙酯文献

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