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2,4,6-三氨基嘧啶

2,4,6-三氨基嘧啶用途

【用途一】
用于抗肿瘤药、抗癌药及氨苯蝶啶、甲氨碟呤等药物的合成
【用途二】
该品是药物氨苯喋啶和氨喋呤的中间体。

2,4,6-三氨基嘧啶名称

[ CAS 号 ]:
1004-38-2

[ 中文名 ]:
2,4,6-三氨基嘧啶

[ 英文名 ]:
Pyrimidin-2,4,6-triamin

[中文别名 ]:

三氨基嘧啶

[英文别名 ]:

TRIAMINOPYRIMIDINE
EINECS 213-720-7
1,3,5-triaminopyrimidine
Pyrimidine-2,4,6-triamine
2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE
6-TriaMinopyriMidine
2,4,6-Pyrimidinetriamine
MFCD00006100
2,4,6-triamino pyrimidine
2,4,6-Triaminopyrimidin

2,4,6-三氨基嘧啶物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
530.8±53.0 °C at 760 mmHg

[ 熔点 ]:
249-251 °C(lit.)

[ 分子式 ]:
C₄H₇N₅

[ 分子量 ]:
125.132

[ 闪点 ]:
308.2±18.1 °C

[ 精确质量 ]:
125.070145

[ PSA ]:
103.84000

[ LogP ]:
-1.01

[ 外观性状 ]:
灰白色粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.793

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
36.5 g/L (20 ºC)

2,4,6-三氨基嘧啶MSDS

2,4,6-三氨基嘧啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933599090

2,4,6-三氨基嘧啶合成路线

2,4,6-三氨基嘧啶上下游产品

2,4,6-三氨基嘧啶上游产品

2,4,6-三氨基嘧啶下游产品

2,4,6-三氨基嘧啶制备

由氰乙酸乙酯经氨化生成氰乙酰胺，再经消除反应得到丙二腈，最后经环合制得2,4,6-三氨基嘧啶。

2,4,6-三氨基嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2,4,6-三氨基嘧啶文献

Determination of the driving force for the sodium pump (ENa) and of active and passive conductances (GNa and Gsh) in isolated toad skin: influence of antidiuretic hormone.

Gen. Pharmacol. 18(6) , 589-92, (1987)

1. Values of the sodium potential (ENa), active conductance (GNa) and passive conductance (Gsh) were measured in the isolated skin of the toad Pleurodema thaul placed in an Ussing chamber, and Isaacso...

Mechanism of ammonium transport by intestinal segments following urinary diversion: evidence for ionized NH4+ transport via K(+)-pathways.

J. Urol. 148(2 Pt 1) , 453-7, (1992)

Using a previously reported in vivo intestinal perfusion model in the rat, we have shown that net total ammonium absorption accounts for the majority of the acid load resulting from urinary intestinal...

Factors affecting the potassium concentration at the mucosal surface of the proximal and the distal colon of guinea pig.

Gut 31(1) , 64-9, (1990)

K+ concentrations were measured in vitro with K+ sensitive microelectrodes in the microclimate at the luminal cell surface of the colon of guinea pigs. The serosal K+ concentration was mostly 5.4 mmol...

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