GSK1790627

Modify Date: 2024-01-14 11:08:00

GSK1790627 structure	Common Name	GSK1790627
	CAS Number	871701-87-0	Molecular Weight	573.36
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₁FIN₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GSK1790627

GSK1790627 is the N-deacetylated metabolite of Trametinib (HY-10999). Trametinib is an orally active MEK inhibitor, and activates autophagy and induces apoptosis[1].

Name	GSK1790627

Description	GSK1790627 is the N-deacetylated metabolite of Trametinib (HY-10999). Trametinib is an orally active MEK inhibitor, and activates autophagy and induces apoptosis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> MEK
In Vitro	GSK1790627 (1、10 和 50 μM，60 分钟) 在重组 hNAT 酶存在下是稳定的[1]。
References	[1]. Ho MY, et al. Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers. Xenobiotica. 2014 Apr;44(4):352-68.

Molecular Formula	C₂₄H₂₁FIN₅O₃
Molecular Weight	573.36

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GSK1790627

Use of GSK1790627

Names

GSK1790627 Biological Activity

Chemical & Physical Properties