Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GSK1790627
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Purity: 98.0%
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871701-87-0

871701-87-0 structure

871701-87-0 structure

Name: GSK1790627
Chemical Name: GSK1790627
CAS Number: 871701-87-0
Molecular Formula: C₂₄H₂₁FIN₅O₃
Molecular Weight: 573.36
Catalog: Signaling Pathways MAPK/ERK Pathway MEK
Create Date: 2023-04-24 11:30:07
Modify Date: 2024-01-14 11:08:00
GSK1790627 is the N-deacetylated metabolite of Trametinib (HY-10999). Trametinib is an orally active MEK inhibitor, and activates autophagy and induces apoptosis[1].

Name	GSK1790627

Description	GSK1790627 is the N-deacetylated metabolite of Trametinib (HY-10999). Trametinib is an orally active MEK inhibitor, and activates autophagy and induces apoptosis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> MEK
In Vitro	GSK1790627 (1、10 和 50 μM，60 分钟) 在重组 hNAT 酶存在下是稳定的[1]。
References	[1]. Ho MY, et al. Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers. Xenobiotica. 2014 Apr;44(4):352-68.

Molecular Formula	C₂₄H₂₁FIN₅O₃
Molecular Weight	573.36

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