proglumetacin

Modify Date: 2025-08-21 20:59:08

proglumetacin structure	Common Name	proglumetacin
	CAS Number	57132-53-3	Molecular Weight	844.43
	Density	1.22 g/cm3	Boiling Point	900.4ºC at 760 mmHg
	Molecular Formula	C₄₆H₅₈ClN₅O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	498.3ºC

Use of proglumetacin

Proglumetacin is an orally active and potent cyclo-oxygenase inhibitor. Proglumetacin can inhibits SARS-CoV Mpro (main protease of the SARS-CoV-2), with an AC50 of 8.9 μM (activity concentration at half maximal activity). Proglumetacin has anti-inflammatory activity, can be used for inflammation (such as Rheumatoid arthritis, and Allergic air pouch inflammation) research[1][2][3].

Name	proglumetacin
Synonym	More Synonyms

Description	Proglumetacin is an orally active and potent cyclo-oxygenase inhibitor. Proglumetacin can inhibits SARS-CoV Mpro (main protease of the SARS-CoV-2), with an AC50 of 8.9 μM (activity concentration at half maximal activity). Proglumetacin has anti-inflammatory activity, can be used for inflammation (such as Rheumatoid arthritis, and Allergic air pouch inflammation) research[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology
In Vitro	Proglumetacin strongly inhibits 5-HETE formation, with an IC50 of 1.5 μM[2]. Proglumetacin inhibits leukocyte migration by inhibiting the production of the chemotactic cyclo-oxygenase product thromboxane B2[2].
In Vivo	Proglumetacin (Sprague-Dawley rats, 0-30 mg/kg, Orally, once) dose-dependently inhibits accumulation of pouch exudate[1]. Animal Model: Sprague-Dawley rats (6 weeks) Dosage: 0, 0.3, 3, 9, 30 mg/kg Administration: Orally, once Result: Caused dose-dependent reduction of leukocyte migration into the pouch exudate, caused 49.2% inhibition at 30 mg/kg; and markedly decreased the prostaglandin E2 content of the pouch exudate, but tended to increase the leukotriene B 4 content.
References	[1]. [1] NaohikoOno, et al. Effects of proglumetacin maleate and its major metabolites on allergic air pouch inflammation in rats. Eur J Pharmacol. 1987;142(2):245-251. [2]. [2] Ono N, et al. Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug (4). Mode of action on anti-inflammatory activity. Japanese Journal of Pharmacology, 1986, 42(3):431-9. [3]. [3] Alves VM, et al. QSAR Modeling of SARS-CoV Mpro Inhibitors Identifies Sufugolix, Cenicriviroc, Proglumetacin, and other Drugs as Candidates for Repurposing against SARS-CoV-2. Mol Inform. 2021 Jan;40(1):e2000113. [4]. [4] Bozsoky S, Zahumenszky Z. A 3-month, double-blind study of proglumetacin and naproxen in the treatment of rheumatoid arthritis. Curr Med Res Opin. 1982;8(2):89-96.

Density	1.22 g/cm3
Boiling Point	900.4ºC at 760 mmHg
Molecular Formula	C₄₆H₅₈ClN₅O₈
Molecular Weight	844.43
Flash Point	498.3ºC
Exact Mass	843.39700
PSA	139.72000
LogP	6.43090
Index of Refraction	1.592

PROGLUMETACIN

Proglumetacina

Proglumetacine

3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate

Proglumetacinum

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

proglumetacin

Use of proglumetacin

Names

proglumetacin Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.