Norphenylephrine hydrochloride

Modify Date: 2024-01-08 16:56:59

Norphenylephrine hydrochloride structure	Common Name	Norphenylephrine hydrochloride
	CAS Number	4779-94-6	Molecular Weight	189.64
	Density	1.249g/cm3	Boiling Point	360.7ºC at 760mmHg
	Molecular Formula	C₈H₁₂ClNO₂	Melting Point	162-164ºC(lit.)
	MSDS	Chinese USA	Flash Point	172ºC
	Symbol	GHS07	Signal Word	Warning

Use of Norphenylephrine hydrochloride

Norfenefrine hydrochloride is an orally active, endogenously found α-adrenergic agonist and can be used for the research of female stress incontinence[1][2].

Name	Norphenylephrine hydrochloride
Synonym	More Synonyms

Description	Norfenefrine hydrochloride is an orally active, endogenously found α-adrenergic agonist and can be used for the research of female stress incontinence[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
References	[1]. [2].

Description

Norfenefrine hydrochloride is an orally active, endogenously found α-adrenergic agonist and can be used for the research of female stress incontinence[1][2].

Related Catalog

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

References

[1].

[2].

Density	1.249g/cm3
Boiling Point	360.7ºC at 760mmHg
Melting Point	162-164ºC(lit.)
Molecular Formula	C₈H₁₂ClNO₂
Molecular Weight	189.64
Flash Point	172ºC
Exact Mass	189.055649
PSA	66.48000
LogP	1.88660

Norphenylephrine hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN7400000

CHEMICAL NAME :: Benzyl alcohol, alpha-aminomethyl-3-hydroxy-, hydrochloride

CAS REGISTRY NUMBER :: 4779-94-6

LAST UPDATED :: 199712

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C8-H11-N-O2.Cl-H

MOLECULAR WEIGHT :: 189.66

WISWESSER LINE NOTATION :: QR CYQM1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,561,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,561,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,561,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,1587,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,561,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,440,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,1587,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,440,1952

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DN7400000

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Literature: Alpatova, T. V.; Klimova, A. D.; Kulinskii, V. I.; Mirzoyan, V. S.; Mirzoyan, A. T.; Yashunskii, V. G. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 4 p. 262 - 266 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 4 p. 444 - 449

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MFCD00012879

3-(2-Amino-1-hydroxyethyl)phenol hydrochloride (1:1)

UNII:1FCN9TAU6R

Benzyl alcohol, .α.-aminomethyl-3-hydroxy-, hydrochloride

Benzenemethanol, α-(aminomethyl)-3-hydroxy-, hydrochloride (1:1)

EINECS 225-323-6

Benzenemethanol, α- (aminomethyl)-3-hydroxy-, hydrochloride

rac Norphenylephrine Hydrochloride(Phenylephrine Impurity A)

Benzyl alcohol, α-aminomethyl-3-hydroxy-, hydrochloride

Phenylephrine Impurity 16

Norphenylephrine hydrochloride

Use of Norphenylephrine hydrochloride

Names