JTC-017

Modify Date: 2024-01-31 01:14:10

JTC-017 Structure
JTC-017 structure
Common Name JTC-017
CAS Number 357330-77-9 Molecular Weight 490.40100
Density N/A Boiling Point N/A
Molecular Formula C20H25Cl2N3O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JTC-017


JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].

 Names

Name 3,5-dichloro-N-[5-(diethylsulfamoyl)-3-(dimethylamino)-2-methoxyphenyl]-4-hydroxybenzamide
Synonym More Synonyms

 JTC-017 Biological Activity

Description JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].
Related Catalog
References

[1]. Saito K, et al. Corticotropin-releasing hormone receptor 1 antagonist blocks brain-gut activation induced by colonic distention in rats. Gastroenterology. 2005;129(5):1533-1543.  

 Chemical & Physical Properties

Molecular Formula C20H25Cl2N3O5S
Molecular Weight 490.40100
Exact Mass 489.08900
PSA 111.05000
LogP 5.52120

 Synonyms

Benzamide,3,5-dichloro-N-(5-((diethylamino)sulfonyl)-3-(dimethylamino)-2-methoxyphenyl)-4-hydroxy
JTC-017
UNII-7F4TZ7XGMO
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