357330-77-9

357330-77-9 structure

Name: JTC-017
Chemical Name: 3,5-dichloro-N-[5-(diethylsulfamoyl)-3-(dimethylamino)-2-methoxyphenyl]-4-hydroxybenzamide
CAS Number: 357330-77-9
Molecular Formula: C₂₀H₂₅Cl₂N₃O₅S
Molecular Weight: 490.40100
Catalog: Signaling Pathways GPCR/G Protein CRFR
Create Date: 2016-05-31 23:45:29
Modify Date: 2025-09-24 10:03:00
JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].

Name	3,5-dichloro-N-[5-(diethylsulfamoyl)-3-(dimethylamino)-2-methoxyphenyl]-4-hydroxybenzamide
Synonyms	Benzamide,3,5-dichloro-N-(5-((diethylamino)sulfonyl)-3-(dimethylamino)-2-methoxyphenyl)-4-hydroxy JTC-017 UNII-7F4TZ7XGMO

Description	JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Metabolic Disease
References	[1]. Saito K, et al. Corticotropin-releasing hormone receptor 1 antagonist blocks brain-gut activation induced by colonic distention in rats. Gastroenterology. 2005;129(5):1533-1543.