(+)-Sotalol

Modify Date: 2024-01-10 16:48:33

(+)-Sotalol structure	Common Name	(+)-Sotalol
	CAS Number	30236-32-9	Molecular Weight	272.36400
	Density	1.239g/cm3	Boiling Point	443.3ºC at 760mmHg
	Molecular Formula	C₁₂H₂₀N₂O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	221.9ºC

Use of (+)-Sotalol

(+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3].

Name	(+)-(s)-n-[4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide
Synonym	More Synonyms

Description	(+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	β-adrenoceptor
In Vitro	(+)-Sotalol (1, 10, 100 µM) 在离体心肌中增加动作电位持续时间[2]。 (+)-Sotalol (100 μM，60 分钟) 可延长三种细胞类型 (心内膜、心外膜、心肌中部和透壁细胞) 的动作电位[4]。
In Vivo	(+)-Sotalol (8 mg/kg，静脉注射) 抑制程序刺激诱导的犬室性心动过速[3]。 Animal Model: Programmed stimulated Dogs[3] Dosage: 8 mg/kg Administration: Intravenous injection (i.v.) Result: Increased normal zone ventricular refractoriness, and prevented propagation of programmed ventricular extra-stimuli of sufficient prematurity to elicit tachyarrhythmias.
References	[1]. ChuanjunLu, et al. The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol. Tetrahedron: Asymmetry.Volume 22, Issue 7.11 April 2011, Pages 722-727 [2]. Kato R, et al. Electrophysiologic effects of the levo- and dextrorotatory isomers of sotalol in isolated cardiac muscle and their in vivo pharmacokinetics. J Am Coll Cardiol. 1986 Jan;7(1):116-25. [3]. Lynch JJ, et al. Antiarrhythmic and antifibrillatory actions of the levo- and dextrorotatory isomers of sotalol. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1132-41. [4]. Serge Sicouri, et al. d-Sotalol Induces Marked Action Potential Prolongation and Early Afterdepolarizations in M but Not Epicardial or Endocardial Cells of the Canine Ventricle. Journal of Cardiovascular Pharmacology and Therapeuticshttps. 2016.

Density	1.239g/cm3
Boiling Point	443.3ºC at 760mmHg
Molecular Formula	C₁₂H₂₀N₂O₃S
Molecular Weight	272.36400
Flash Point	221.9ºC
Exact Mass	272.11900
PSA	86.81000
LogP	2.63420
Index of Refraction	1.57

Sotolol

Betacotdone

d,l-sotalol

SORBITOL

(+)-Sotalol

Use of (+)-Sotalol

Names

(+)-Sotalol Biological Activity

Chemical & Physical Properties

Synonyms