Tubulin polymerization-IN-41
Modify Date: 2023-02-04 11:05:47
Tubulin polymerization-IN-41 structure
|
Common Name | Tubulin polymerization-IN-41 | ||
|---|---|---|---|---|
| CAS Number | 2804026-81-9 | Molecular Weight | 435.26 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H16Cl2N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tubulin polymerization-IN-41Tubulin polymerization-IN-41 is a potent tubulin polymerization inhibitor with the IC50 of 2.61 μM. Tubulin polymerization-IN-41 targets the Colchicine-binding site of tubulin. Tubulin polymerization-IN-41 has anticancer effects[1]. |
| Name | Tubulin polymerization-IN-41 |
|---|
| Description | Tubulin polymerization-IN-41 is a potent tubulin polymerization inhibitor with the IC50 of 2.61 μM. Tubulin polymerization-IN-41 targets the Colchicine-binding site of tubulin. Tubulin polymerization-IN-41 has anticancer effects[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Tubulin polymerization-IN-41 (compound C3) displays remarkable antiproliferative activities with IC50 values of 6.3 nM, 9.2 nM, 8.3 nM, and 8.7 nM for K562, MCF-7, HT29, and HCT116 cells, respectively. Additionally, Tubulin polymerization-IN-41 shows marked activity against Paclitaxel-resistant MCF-7 cells and A549 cells[1]. Tubulin polymerization-IN-41 (compound C3; 5-20 nM) downregulates the expression of acetyl-α-tubulin (Ac-α-tubulin) and upregulated the expression of detyrosinated-α-tubulin (DeY-α-tubulin) in a concentration-dependent manner[1]. Tubulin polymerization-IN-41 (compound C3; 5-20 nM; 24 hours) could arrest cancer cells in the G2/M phase, and induces MCF-7 cells apoptosis in a concentration-dependent manner[1]. Tubulin polymerization-IN-41 (compound C3; 5-20 nM; 24 hours) reduces Ser216 phosphorylation, resulting in cdc2 Tyr15 dephosphorylation and Thr161 phosphorylation, which ultimately leads to the activation of subsequent cdc2/cyclin B1 complex[1]. Cell Cycle Analysis[1] Cell Line: MCF-7 cells Concentration: 5 nM, 10 nM, 20 nM Incubation Time: 24 h Result: Could arrest cancer cells in the G2/M phase. Apoptosis Analysis[1] Cell Line: MCF-7 cells Concentration: 5 nM, 10 nM, 20 nM Incubation Time: 24 h Result: Induced MCF-7 cells apoptosis. Western Blot Analysis[1] Cell Line: MCF-7 cells Concentration: 5 nM, 10 nM, 20 nM Incubation Time: 24 h Result: Induced cdc25c activation. |
| In Vivo | Tubulin polymerization-IN-41 (compound C3; 5-20 mg/kg; i.p; every two days; for 21 consecutive days) exhibits the significant potency of tumor growth inhibition in a dose dependence without weight loss in the drug-treated period[1]. Animal Model: Five-week-old female athymic nude mice injected with MCF-7 cells[1] Dosage: 5, 10, and 20 mg/kg Administration: Intraperitoneal injection; every two days; for 21 consecutive days Result: Exhibited the significant potency of tumor growth inhibition in a dose dependence without weight loss in the drug-treated period. |
| References |
| Molecular Formula | C20H16Cl2N2O5 |
|---|---|
| Molecular Weight | 435.26 |