MPO-IN-5

Modify Date: 2024-01-27 13:42:58

MPO-IN-5 structure	Common Name	MPO-IN-5
	CAS Number	2476764-11-9	Molecular Weight	428.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₄N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MPO-IN-5

MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].

Name	MPO-IN-5

Description	MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 0.22 μM (MPO peroxidation), 2.8 μM (hERG binding), 30 μM (TPO)[1]
References	[1]. Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorg Med Chem. 2020 Jun 15;28(12):115548.

Molecular Formula	C₂₄H₂₄N₆O₂
Molecular Weight	428.49

MPO-IN-5

Use of MPO-IN-5

Names

MPO-IN-5 Biological Activity

Chemical & Physical Properties