L791943

Modify Date: 2024-01-09 20:17:32

L791943 Structure
L791943 structure
Common Name L791943
CAS Number 192767-01-4 Molecular Weight 573.38
Density N/A Boiling Point N/A
Molecular Formula C24H17F10NO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of L791943


L791943 is a potent, selective Phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 4.2 nM.

 Names

Name L791943

 L791943 Biological Activity

Description L791943 is a potent, selective Phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 4.2 nM.
Related Catalog
Target

IC50: 4.2 nM (Phosphodiesterase-4)[1]

In Vitro The extent of metabolism of L791943 is evaluated in vitro in rat hepatocytes and compared to the data obtaine with CDP-840. In our standard incubation conditions, >98% of the parent drug remain in the case of L791943 whereas only 11% of CDP-840 is left intact[2].
References

[1]. Richard Frenette, et al. Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters. Bioorg Med Chem Lett. 2002 Oct 21;12(20):3009-13.

[2]. Guay D, et al. Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1457-61.

 Chemical & Physical Properties

Molecular Formula C24H17F10NO4
Molecular Weight 573.38
Storage condition 2-8℃
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