Tezosentan-d4

Modify Date: 2023-01-16 18:47:44

Tezosentan-d4 structure	Common Name	Tezosentan-d4
	CAS Number	1794707-10-0	Molecular Weight	609.65
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₃D₄N₉O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tezosentan-d4

Tezosentan-d4 (RO 610612-d4) is the deuterium labeled Tezosentan. Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively[1][2].

Name	Tezosentan-d4

Description	Tezosentan-d4 (RO 610612-d4) is the deuterium labeled Tezosentan. Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Clozel M, et al. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther. 1999 Aug;290(2):840-6.

Molecular Formula	C₂₇H₂₃D₄N₉O₆S
Molecular Weight	609.65