GW284543 hydrochloride

Modify Date: 2024-04-11 12:51:13

GW284543 hydrochloride Structure
GW284543 hydrochloride structure
Common Name GW284543 hydrochloride
CAS Number 179246-08-3 Molecular Weight 408.88
Density N/A Boiling Point N/A
Molecular Formula C23H21ClN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GW284543 hydrochloride


GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].

 Names

Name GW 284543 hydrochloride-UNC 10225170 hydrochloride

 GW284543 hydrochloride Biological Activity

Description GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].
Related Catalog
Target

MEK5

In Vitro GW284543 (10 and 20 μM; 6 h) treatment inhibits MEK5 in a dose-dependent manner and reduces pERK5[1]. Western Blot Analysis[1] Cell Line: MIA PaCa-2 cells Concentration: 10 and 20 μM Incubation Time: 6 hours Result: Reduced phosphorylation of ERK5, and decreased endogenous MYC protein.
References

[1]. Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7.  

 Chemical & Physical Properties

Molecular Formula C23H21ClN2O3
Molecular Weight 408.88
Storage condition Sealed in dry,Room Temperature
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