GW284543 hydrochloride

Names

[ Name ]:
GW284543 hydrochloride

Biological Activity

[Description]:

GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> MEK

[Target]

MEK5

[In Vitro]

GW284543 (10 and 20 μM; 6 h) treatment inhibits MEK5 in a dose-dependent manner and reduces pERK5[1]. Western Blot Analysis[1] Cell Line: MIA PaCa-2 cells Concentration: 10 and 20 μM Incubation Time: 6 hours Result: Reduced phosphorylation of ERK5, and decreased endogenous MYC protein.

[References]

[1]. Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₁ClN₂O₃

[ Molecular Weight ]:
408.88

[ Storage condition ]:
Sealed in dry,Room Temperature

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.