FR173657

Modify Date: 2024-01-31 09:43:48

FR173657 structure	Common Name	FR173657
	CAS Number	167838-64-4	Molecular Weight	592.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₂₇Cl₂N₅O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FR173657

FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease[1].

Name	FR173657

Description	FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor
Target	0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively[1]
References	[1]. Asano M, et al. The identification of an orally active, nonpeptide bradykinin B2 receptor antagonist, FR173657. Br J Pharmacol. 1997 Feb;120(4):617-24.

Molecular Formula	C₃₀H₂₇Cl₂N₅O₄
Molecular Weight	592.47

Dichloromethane
CAS#:75-09-2

Polyacrylic acid
CAS#:9003-01-4

sodium carbonate
CAS#:497-19-8

Silicon dioxide
CAS#:7631-86-9

Triethanolamine
CAS#:102-71-6

Demeton
CAS#:126-75-0

Water
CAS#:7732-18-5

4-(4-Piperidinyl)morpholine dihydrochloride
CAS#:53617-35-9

Diclofenac sodium
CAS#:15307-79-6

Budesonide
CAS#:51372-29-3

FR173657

Use of FR173657

Names

FR173657 Biological Activity

Chemical & Physical Properties