FR173657

Names

[ Name ]:
FR173657

Biological Activity

[Description]:

FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor

[Target]

0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively[1]

[References]

[1]. Asano M, et al. The identification of an orally active, nonpeptide bradykinin B2 receptor antagonist, FR173657. Br J Pharmacol. 1997 Feb;120(4):617-24.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₂₇Cl₂N₅O₄

[ Molecular Weight ]:
592.47

Related Compounds

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