Fomivirsen

Modify Date: 2024-01-03 19:53:04

Fomivirsen structure	Common Name	Fomivirsen
	CAS Number	144245-52-3	Molecular Weight	6682.40000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀₄H₂₆₃N₆₃O₁₁₄P₂₀S₂₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Fomivirsen

Fomivirsen (ISIS-2922 free base) is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation[1][2].

Name	Fomivirsen
Synonym	More Synonyms

Description	Fomivirsen (ISIS-2922 free base) is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> CMV
References	[1]. M D de Smet, et al. Fomivirsen- a phosphorothioate oligonucleotide for the treatment of CMV retinitis. Ocul Immunol Inflamm. 1999 Dec;7(3-4):189-98. [2]. Anna Kilanowska, et al. In vivo and in vitro studies of antisense oligonucleotides – a review. (Review Article) RSC Adv., 2020, 10, 34501-34516.

Description

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> CMV

References

[1]. M D de Smet, et al. Fomivirsen- a phosphorothioate oligonucleotide for the treatment of CMV retinitis. Ocul Immunol Inflamm. 1999 Dec;7(3-4):189-98.

[2]. Anna Kilanowska, et al. In vivo and in vitro studies of antisense oligonucleotides – a review. (Review Article) RSC Adv., 2020, 10, 34501-34516.

Molecular Formula	C₂₀₄H₂₆₃N₆₃O₁₁₄P₂₀S₂₀
Molecular Weight	6682.40000
Exact Mass	6677.59000
PSA	3279.10000
LogP	15.76190

Isis 2922

Fomivirsen

Use of Fomivirsen

Names

Fomivirsen Biological Activity

Chemical & Physical Properties

Synonyms